三维适形放疗治疗晚期食管鳞癌23例疗效分析

Effect of Three-dimentional Conformal Radiotherapy for 23 Advanced Esophageal Squamous Cancer Cases

目的探讨三维适形放疗治疗晚期食管鳞癌的临床疗效。方法将23例接受三维适形放疗治疗的晚期食管鳞癌患者设为治疗组,同期接受常规放疗治疗的23例晚期食管鳞癌患者设为对照组,观察两组治疗效果及不良反应。结果治疗组近期放疗有效率82.6%,对照组近期放疗有效率69.6%,差异具有统计学意义(P<0.05);治疗组1年生存率78.2%,对照组1年生存率60.9%,差异具有统计学意义(P<0.05);治疗组血液不良反应发生率47.8%,对照组不良反应发生率69.6%,差异具有统计学意义(P<0.05)。结论三维适形放疗能减少靶区周围组织放射剂量,提高生存率,减少不良反应,近期疗效显著。

Objective To observe the effect of three- dimensional conformal radiotherapy for advanced esophageal squamous cancer.Methods The treatment group( 23 cases) received three- dimensional conformal radiotherapy,and the control group( 23 cases) were treated by conventional radiotherapy. The effects of each group were observed after the treatment. Results The recent effective rate was 82. 6%in the treatment group and 69. 6% in the control group. 1 year survival rate was 78. 2% and 60. 9% in treatment group and control group respectively,and the occurring rate of haematological toxicity was 47. 8% and 69. 6% in treatment group and control group respectively.There was statistical difference in recent effective rate,1 year survival rate,occurring rate of haematological toxicity between two groups( P< 0. 05). Conclusion Three- dimensional conformal radiotherapy can reduce the radiotherapy dose of target adjacent tissues,increase the local control rate and survival rate,decrease the occurring rate of haematological toxicity,and have a significant recent effect on patients with advanced squamous esophageal cancer.