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内质网应激在慢性HBV感染发病中的作用 被引量:1

Endoplasmic reticulum stress in chronic HBV infection
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摘要 乙型肝炎病毒(Hepatitis B Virus,HBV)慢性感染在慢性乙型肝炎-肝硬化-肝癌的进展中起着重要作用。内质网应激(endoplasmic reticulum stress,ERS)是一种细胞的自我防御机制,适度的ERS能促进未折叠或错误折叠蛋白的降解,对细胞存活起保护作用,但持续的ERS则会引起细胞不可逆损伤甚至细胞凋亡。大量研究证实,持续的HBV复制和表达可触发ERS,ERS与HBV感染后肝脏非可控性炎症的发生发展和恶性转化密切相关,但确切的调控机制尚未阐明1-2。进一步阐明ERS在肝脏疾病中的作用机制,将对肝脏疾病的防治具有重要的临床意义。本文就ERS在慢性HBV感染发病机制中的作用进行综述。
出处 《中华临床感染病杂志》 CAS 2013年第5期316-319,共4页 Chinese Journal of Clinical Infectious Diseases
基金 国家自然科学基金
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参考文献32

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