急性肝衰竭病因与预后分析

Studies on Etiology and Prognosis of Patients with Acute Liver Failure

目的:根据最新指南回顾性分析急性肝衰竭(acute liver failure,ALF)病因构成与预后。方法:通过检索及病例查阅共确定61名ALF患者,分析其病因、实验室指标及预后。结果:乙型肝炎病毒(hepatitis B virus,HBV)感染为ALF的主要病因,占85.2%。死亡组与存活组比较,除丙氨酸氨基转移酶(alanine aminotransferase,ALT)、肌酐(creatinine,Cr)外,其他指标如年龄、白蛋白(albumin,Alb)、总胆红素(total bilirubin,TBil)、血清钠、凝血酶原时间(prothrombin time,PT)、国际标准化比值(international normalized ratio,INR)组间差异均有统计学意义(P<0.05)。结论:HBV感染是湖北省及周边地区ALF的主要发病原因。年龄、白蛋白、总胆红素、血清钠、凝血酶原时间、国际标准化比值等与ALF预后密切相关。

Objective To review the etiologic factors and prognosis in patients with acute liver failure retrospectively according to the new standard of ALF.Methods A total of 61 patients with ALF were identified,and then the causes,laboratory profiles and prognosis were investigated.Results The most common etiology of ALF in Hubei province and neighboring regions was HBV infection accounted for 85.2%.The indexes of age,Alb,total bilirubin,serum sodium level,PT and INR excluding ALT and Cr were significantly different between death group and survival group(P < 0.05).Conclusion The most common etiology of ALF was HBV infection in Hubei province and neighboring regions.The age,albumin,total bilirubin,serum sodium level,prothrombin time and international normalized ratio are important prognostic factors.