摘要
目的探讨伴t(1;19)/TCF3-PBXl的儿童急性淋巴细胞白血病(acute lymphoblastic leukemia,ALL)的临床及生物学特征。方法分析17例t(1;19)儿童ALL患者,包括细胞形态学、血常规、TCF3-PBXl融合基因及临床特征。结果 17例TCF3-PBXl阳性的儿童ALL占同期儿童ALL的5.57%;男8例,女9例,中位年龄6.4(1~13)岁,完全缓解率为100%;平衡易位6例,不平衡易位9例,两组比较差异无显著性。结论儿童t(1;19)/TCF3-PBXl阳性的ALL有着独特的临床和实验室特点,治疗缓解率高。
Objective To explore clinical and biological features of TCF3-PBX1 fusion gene positive in Children with acute lymphoblastic leukemia acute lymphoblastic leukemia (ALL). Methods We analysed cell morphology, routine blood test results, TCF3-PBXl fusion gene and clinical features in the 17 cases. Results The incidence of 17 TCR3-PBX1-positive children’s ALL was 5.57%of the total. ALL patients of them, 8 male cases, 9 female cases. The median age was 6.4 (1~13) years old. Complete remission rate was 100%;6 cases of balanced translocation. Unbalanced translocation 9 cases. No signiifcant difference between the two groups. Conclusion TCF3-PBX1-positive children’s ALL had unique clinical and pathological features with high remissiion rate.
出处
《中国医学前沿杂志（电子版）》
2014年第2期34-37,共4页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
基金
江西省卫生厅科技计划(20131145)
