血浆心型脂肪酸结合蛋白水平对急性冠状动脉综合征辅助诊断的临床价值探讨

Clinical value of serum heart type fatty acid binding protein levels in patients with acute coronary syndrome diagnosis

目的探讨血浆心型脂肪酸结合蛋白(H-FABP)水平对急性冠状动脉综合征(ACS)辅助诊断的临床价值。方法选取2011年1月至2013年1月本院收治的ACS患者89例,设为ACS组,选取同期本院收治的稳定型心绞痛患者90例,设为稳定型心绞痛组,选取同期在本院进行健康体检的90例健康志愿者,设为健康组,比较3组研究对象的血浆H-FABP水平及不同冠状动脉狭窄程度、病变支数、ACS患者的血浆H-FABP水平。结果 ACS组患者的H-FABP水平显著高于稳定型心绞痛组和健康志愿者组,并具有显著性差异(P<0.05);冠状动脉狭窄重度ACS患者的H-FABP水平显著高于中度、轻度ACS患者,并具有显著性差异(P<0.05);多支病变ACS患者的H-FABP水平显著高于2支、1支ACS患者,并具有显著性差异(P<0.05)。结论通过对血浆H-FABP水平的检测可以很好地判断ACS患者预后水平,对于该病的辅助诊断具有积极意义,值得临床推广。

Objective To investigate the changes of serum heart type fatty acid binding protein (H-FABP) levels in patients with acute coronary syndrome (ACS) in clinical diagnosis. Methods 89 ACS patients from 2011 January to 2013 January in our hospital were cases, group ACS, 90 patients were admitted to our hospital in stable angina pectoris, with stable angina group, select the same period 90 cases of healthy health volunteers in the hospital, as healthy group, plasma than H-FABP the level of plasma H-FABP level was 3 groups of subjects and different degree of coronary artery stenosis, number of diseased patients, ACS. Results ACS group of patients with H-FABP was signiifcantly higher than that in stable angina group and healthy volunteers, the result had signiifcant difference (P<0.05);coronary artery stenosis in patients with severe ACS H-FABP level was signiifcantly higher than that in moderate, mild ACS patients, with signiifcant difference (P<0.05);multi-vessel lesions in patients with ACS H-FABP level is signiifcantly higher than that of 2, 1 ACS patients, and has signiifcant difference (P<0.05). Conclusion Through the detection of plasma H-FABP levels can be a very good prognosis in patients with ACS, which has a positive signiifcance for the diagnosis of the disease, is worth the clinical promotion.