期刊文献+

从临床视角看待胃癌的个体化治疗 被引量:1

下载PDF
导出
摘要 随着对肿瘤临床病理认识的深入理解以及分子生物学的研究进展,'one fits all'的粗放型肿瘤治疗模式正在向'personalization of cancer care'的个体化治疗模式转变。众所周知,在所有恶性肿瘤中,胃癌的异质性尤其显著,不同发生部位、不同发病机制、不同病理分型乃至不同的分子分型导致了完全不同的生物学行为。甚至许多学者提出,胃癌不是一种疾病,而是一组疾病,因此,即使同为胃黏膜上皮来源的腺癌,'同病异治'的个体化治疗模式也尤为重要,毕竟针对性最强的治疗策略方可能实现'对症下药',带来最大受益。
作者 张小田
出处 《中国医学前沿杂志(电子版)》 2012年第5期21-24,共4页 Chinese Journal of the Frontiers of Medical Science(Electronic Version)
  • 相关文献

参考文献11

  • 1Ajani JA,Rodriguez W,Bodoky G. Multicenter phase Ⅲ comparison of cisplatin/S-1 with cisplatin/infusional fluorouracil in advanced gastric or gastroesophageal adenocarcinoma study:the FLAGS trial[J].Journal of Clinical Oncology,2010,(09):1547-1553.doi:10.1200/JCO.2009.25.4706.
  • 2Narahara H,Iishi H,Imamura H. Randomized phase Ⅲstudy comparing the efficacy and safety of irinotecan plus S-1 with S-1 alone as first-line treatment for advanced gastric cancer (study GC0301/TOP-002)[J].Gastric Cancer:Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association,2011,(01):72-80.
  • 3Boku N,Yamamoto S,Fukuda H. Fluorouracil versus combination of irinotecan plus cisplatin versus S-1 in metastatic gastric cancer:randomised phase 3 study[J].The Lancet Oncology,2009,(11):1063-1069.
  • 4Ajani JA,Moiseyenko VM,Tjulandin S. Clinical benefit with docetaxel plus fluorouracil and cisplatin compared with cisplatin and fluorouracil in a phase Ⅲ trial of advanced gastric or gastroesophageal cancer adcnocarcinoma:the V-325 Study Group[J].Journal of Clinical Oncology,2007,(22):3205-3209.
  • 5Kensei Yamaguchi,Masahiro Tada,Noboru Horikoshi. Phase Ⅱ study of paclitaxel with 3-h infusion in patients with advanced gastric cancer[J].Gastric Cancer:Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association,2002,(02):90-95.
  • 6Yasunori Emi,Manabu Yamamoto,Ikuo Takahashi. Phase Ⅱ study of weekly paclitaxel by one-hour infusion for advanced gastric cancer[J].Surgery Today,2008,(11):1013-1020.
  • 7Mu(n)oz N,Asvall J. Time trends of intestinal and diffuse types of gastric cancer in Norway[J].International Journal of Cancer,1971,(08):144-157.
  • 8Hanai A,Fujimoto I. Time trends in cancer incidence in Osaka[J].Gan to Kagaku Ryoho(Japanese Journal of Cancer and Chemotherapy),1984,(03):367-376.
  • 9Henson DE,Dittus C,Younes M. Differential Trends in the Intestinal and Diffuse Types of Gastric Carcinoma in the United States,1973-2000:Increase in the Signet Ring Cell Type[J].Archives of Pathology and Laboratory Medicine,2004,(07):765-770.
  • 10Ichikawa W,Takehiro T,Kenichi S. Thymidylate synthase and dihydropyrimidine dehydrogenase gene expression in relation to differentiation of gastric cancer[J].International Journal of Cancer,2004.967-973.

同被引文献21

  • 1沈琳.胃癌综合治疗临床问题与药物治疗新视角[J].中国医学前沿杂志(电子版),2012,4(5):1-3. 被引量:5
  • 2曹其彬,陈士远.胃癌淋巴结转移规律及其清扫范围探讨[J].山东医药,2004,44(36):9-10. 被引量:6
  • 3Chen S, Zhao BW, Li YF, et al. The prognostic value of harvested lymph nodes and the metastatic lymph node ratio for gastric cancer patients : results of a study of 1,101 patients [ J ]. PLoS One ,2012,7 ( 11 ) : e49424.
  • 4Medina-Franco H, Cabrera-Mendoza F, Almaguer-Rosales S, et al. Lymph node ratio as a predictor of survival in gastric carcinoma [ J ]. Am Surg,2013,79(3) :284-289.
  • 5Deng J,Sun D,Pan Y, et al. Ratio between negative and positive lymph nodes is suitable for evaluation the prognosis of gastric cancer patients with positive node metastasis[ J]. PLoS One,2012,7 ( 8 ) : e43925.
  • 6Edge SB,Byrd DR, Compton CC,et al. AJCC cancer staging manual [M]. 7th ed. New York: Springer,2010.31.
  • 7Sun Z, Zbu GL, Lu C, et al. The impaet of N-ratio in minimizing stage migration phenomenon in gastric cancer patients with insufficient number or level of lymph node retrieved: results from a Chinese mono-institutional study in 2159 patients[J]. Ann Oneol,2009,20 : 897 -905.
  • 8Greene FL,Page DL,Fleming ID,et al. AJCC cancer staging manual 6th edition[ M]. New York : Springer,2002.41.
  • 9Coburn NG, Swallow C J, Kiss A, et al. Significant regional variation in adequacy of lymph node assessment and survival in gastric cancer [ J]. Cancer,2006,107:2143-2151.
  • 10刘峥嵘,张静,鲁翀,李国胜,王红岩,徐惠绵.胃上部癌与胃下部癌临床病理特点及预后的对比分析[J].中国普通外科杂志,2008,17(4):299-302. 被引量:15

引证文献1

二级引证文献6

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部