路易体痴呆与帕金森病痴呆的临床诊断和治疗

Clinical diagnosis and treatment of dementia with Lewy body and Parkinson’s disease with dementia

路易体痴呆是仅次于阿尔茨海默病的常见神经系统变性性痴呆,与帕金森病痴呆具有相似的神经病理学基础及临床表现。本文综合了最近的临床研究成果,从路易体痴呆与帕金森病痴呆的关系、临床诊断标准、认知功能评价、精神症状评价、神经病学评价、神经影像学检查以及药物治疗等多个方面进行了论述,并对老年患者的用药安全进行了详细说明。

Dementia with Lewy body (DLB) is the second most common form of dementia caused by neural degeneration after Alzheimer’s disease. It overlaps with Parkinson’s disease with dementia(PDD) in both neuropathology and clinical manifestation. The clinical researches about both DLB and PDD concerned with clinical criteria, cognitive assessment, psychiatric assessment, neurologic assessment, neuroimaging, pharmacotherapy in recent years were reviewed. Drug safety in the elderly was also discussed detailedly.