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慢性粒细胞白血病急变机制的研究进展 被引量:1

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摘要 慢性粒细胞白血病(chronic myelogenous leukemia,CML )是起源于多能造血干细胞的恶性克隆性增殖性疾病。CML 病程通常分为3个阶段,即慢性期(chronic phase,CP )、加速期(accelerate phase,AP )及急变期(blast crisis, BC )。同一疾病的不同演变阶段,其肿瘤细胞的生物学行为、疾病临床表现、治疗方法及预后却截然不同。慢性期主要表现为粒系增生,骨髓、外周血和脾脏中大量粒细胞积聚,主要是接近成熟的中、晚幼粒细胞为主,此阶段患者对于羟基脲、干扰素、温和化疗以及酪氨酸激酶抑制剂等相关治疗反应好,能很快获得完全缓解,部分患者缓解后可以接受异基因造血干细胞移植从而达到长期无病生存。
出处 《中国医学前沿杂志(电子版)》 2011年第3期39-42,共4页 Chinese Journal of the Frontiers of Medical Science(Electronic Version)
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