动脉粥样硬化分子遗传学研究进展与转化医学应用

动脉粥样硬化,是一类由遗传、环境因素及其之间的相互作用引起的复杂性疾病,主要包括冠心病、心肌梗死、脑卒中等。自2007年,已有22项全基因组关联分析研究发现了超过40个动脉粥样硬化相关基因,这极大地推动了动脉粥样硬化的分子遗传学研究进展,并为未来的转化医学研究和临床实践提供了基础。

Artery atherosclerosis is a kind of complex disease caused by genetic factors, environmental factors and their interaction; it includes coronary artery disease, myocardial infarction and stroke. Since the year of 2007, there are 22 genome-wide association studies identifying over 40 artery atherosclerosis related susceptibility genes; it promotes the molecular genetics of artery atherosclerosis to develop rapidly and also indicate that a new era of translational medicine is coming. Based on the genome-wide association studies, gene tests might be useful for prediction of artery atherosclerosis, and how to practice in clinics should be studies in future.