非酒精性脂肪性肝病的保肝药物治疗

Drug treatment for NAFLD

非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD )是一种与胰岛素抵抗(insulin resistance,IR )和遗传易感密切相关的代谢应激性肝脏损伤,其病理学改变与酒精性肝病(alcoholic liver disease,ALD )相似,但患者无过量饮酒史,疾病谱包括非酒精性单纯性脂肪肝(nonalcoholic simple fatty liver,NAFL )、非酒精性脂肪性肝炎(nonalcoholic steatohepatitis, NASH )及其相关肝硬化和肝细胞癌。