血必净注射液治疗儿童病毒性脑炎的疗效观察

The therapeutic effects of Xuebijing injection on children with viral encephalitis

目的探讨血必净治疗儿童病毒性脑炎的疗效。方法 2011年8月～2012年7月在我科住院的病毒性脑炎患儿42例,随机分成对照组和观察组,每组各21例。对照组给予常规治疗,观察组在对照组基础上加用血必净注射液静脉滴注,每12h 1次,连用7d。于入院当日和治疗1周后分别进行危重症评分及格拉斯哥昏迷评分,并记录患儿发热天数、意识障碍时间、抽搐控制时间及住院天数。观察2组患儿治疗前后肿瘤坏死因子-α(TNF-α),白介素-6(IL-6),乳酸脱氢酶(LDH),D-二聚体(D-D)及抗凝血酶-Ⅲ(AT-Ⅲ)的变化。结果观察组患儿发热天数、意识障碍及抽搐持续时间、住院天数均较对照组明显缩短(P均<0.05)。治疗1周后,观察组危重症评分、格拉斯哥评分及AT-Ⅲ水平均高于对照组,而血TNF-α、IL-6、LDH及D-D水平均低于对照组(P均<0.01)。治疗前2组患儿以上各项指标之间无显著性差异(P>0.05)。结论血必净注射液可抑制炎症反应,减轻炎症损伤,纠正凝血紊乱,防止病情恶化,在病毒性脑炎中具有较好的临床疗效。

Objective To observe the therapeutic effects of Xuebijing injection on children with viral encephalitis. Methods 42 children with acute viral encephalitis were randomly divided into two groups(control group and study group),each included 21 cases. Routine medicine therapy was given in control groups.In the Xuebijing-treated group(study group), 1 ml/kg Xuebijing injection was intravenously dripped every 12 hours for consecutive 7 days,on the basis of routine therapy. Glasgow coma score(GCS) and critical illness score were conducted in both admittance and seven days after treatment. The duration of fever, convulsion and consciousness disturbance and length of hospital stay were recorded. The levels of interleukin-6(IL-6), tumor necrosis factor-α(TNF-α), lactate dehydrogenase(LDH), D- dimer(D- D), and antithrombin-Ⅲ(AT- Ⅲ) before and after therapy were detected. Results The days of fever, convulsion, consciousness disturbance and hospital stay were lessened in study group than in control group. One week after treatment in study group, Glasgow coma score(GCS), critical illness score and AT-Ⅲ concentration were significantly enhanced and the levels of TNF- α, IL- 6, LDH and D- D were markedly reduced compared with control group(P<0.01 or 0.05). There were no statistical differences between study and control group on all the above markers before treatment. Conclusion Xuebijing injection plays a benefit role in therapy of acute viral encephalitis by inhibiting inflammatory response, reducing the inflammation damage and correcting coagulation disorder, thus preventing deterioration of illness.