临床分离的幽门螺旋杆菌的多重耐药性的相关分析

Analysis of multiple drug resistance of helicobacter pylori which was separated from clinical samples

目的探析本地区幽门螺旋杆菌(Hp)常用抗生素的多重耐药性,为临床提供依据以指导临床。方法从福建省立医院2012年1月至2012年12月因上消化道症状在该院接受胃镜检查的患者胃粘膜标本中,分离培养Hp菌株,运用药敏试验对分离出的菌株行抗菌药敏感性检测。结果Hp阳性率为31.15%,药敏试验阿莫西林、呋喃唑酮、左氧氟沙星、庆大霉素的敏感性均在88.00%以上,克拉霉素耐药率18.89%,甲硝唑耐药率100%,129株出现了对2种抗生素的混合耐药,12株出现了3种抗生素的混合耐药。结论本地区对甲硝唑及克拉霉素的耐药率较高,临床运用也应考虑单药耐药与多重耐药。

Objective To explore and analyze Multiple Drug Resistance of helicobacter pylori to regular antibi- otics,and to provide evidence for clinical use of antibiotics. Methods Hp strains which were isolated from the specimens of gastric mucosa from clinical samples.The clinical samples were collected from the patients who had undergone gastroscopy due to digestive symptoms in our hospital during January 2012 and December 2012.The Hp strains were cultivated and tested antibiotic sensitivity by medicine sensitive experiment. Re- sults Hp positive rate was 31.14%.Sensitivity rate of amoxicillin,furazolidone,levofloxacin,gentamicin drug sensitive test were all above 88.00%.The drug resistant rate to clarithromycin was 18.89%and to met- ronidazole was 100%.129strains showed the hybrid resistant to two kinds of antibiotics,and 12 strains had Multiple Drug Resistance to three kinds of antibiotics. Conclusions The metronidazole and clarithromycin resistant rate were high in this region,and in clinical treatment it should be paid more attention to both single drug resistance and Multiple Drug Resistance.