基于总过敏原家族的食物过敏原家族分类

Classification of food allergen family based on total allergen family

目的根据过敏原数据库对食品过敏原进行分类。方法从致敏性蛋白结构数据库SDAP(StructuralDatabase of Allergenic Proteins)中获得已知食品过敏原列表,将这些食品过敏原在AllFam数据库中进行整理分类。结果根据分类结果 ,得到涵盖食品过敏原数量最多的五个家族分别是Prolamin superfamily、Bet v1-related protein、EF hand domain、Cupin superfamily和Profilin,他们包含了大约60%的食物过敏原。研究还发现3个交叉过敏原家族,分别是Serpin serine protease inhibitor、Thioredoxin和Triosephosphate isomerase。结论这个分类包含植物性食品过敏原和动物性食品过敏原两大类,并使用了过敏原家族数据库AllFam,为科学研究食品过敏原的结构和功能及动物致敏试验、临床致敏试验的设计和开展提供了客观依据。

Objective To classify food allergens into different food allergen families according to allergen database.Methods The list of food allergen was taken from Structural Database of Allergenic Proteins(SDAP).On the basis of allergen families in AllFam Database,these food allergens were classified into different families.Results The most five families contained approximately 60% food allergens,including Prolamin superfamily,Bet v 1-related protein,EF hand domain,Cupin superfamily and Profilin.Moreover,three cross food allergen families were found,including Serpin serine protease inhibitor,Thioredoxin and Triosephosphate isomerase.Conclusion This classification includes both plant food allergen and animal food allergen.This classification provides an objective basis to the study of the structures and functions of food allergens,animal model for food allergen and the design of clinical experiment.