骨质疏松大鼠运动模型的建立与训练效果评定

Establishment of Exercise Model and Assessment of Its Training effects in Osteoporosis Rats

本研究对3月龄SD纯系雌性大鼠行卵巢切除术,成功复制高转换型骨质疏松模型;在对各运动要素研究基础上,建立了以预防骨质疏松发生为目的的运动模型,并对不同强度运动后骨矿含量变化进行了比较研究。3个月训练后的研究结果指出:适宜运动对卵巢切除大鼠的骨量具有一定的提高作用,骨量在适宜运动范围内随运动强度的增大而增加。同时研究发现,运动对OVX大鼠和SHAM大鼠的影响机制不同:运动对卵巢切除OVX大鼠的作用主要是维持骨量或延缓骨量丢失;而处于生长期 SHAM大鼠的运动效应则在于获得较高的峰值骨量。

An exercise model for preventing osteoporosis was built based on the study of different kinds of exercise factors after successful copy of the high - speed turnover model of osteoporosis three month O VX female SD rats. The change of bone mass after exercise of various intensity was comparatively studied. The results after three month exercise indicated that proper exercise had a positive influence on the improvement of bone mass in OVX rats , and bone mass correlated positively with the intensity of exercise to some degree. It was also showed that exercise had different influence on OVX rats and SHAM rats. For OVX rats, exercise had the function of maintaining bone mass and retarding bone loss, while for SHAM rats, exercise had the function of acquiring relatively high peak value of bone mass.