不同运动强度大鼠心肌间质胶原网络结构重塑的扫描电镜观察

Scanning Electron Microscopic Observations on the Remodeling of Intermyocardial Collagen Network in Different Exercise Intensity Rats

在不同运动强度实验动物模型上,采用扫描电子显微镜对心肌间质胶原网络结构重塑进行了观察研究。结果显示,心肌间质胶原网络结构在心肌、毛细血管及心内膜间以4种方式广泛分布,即“框格式”联接,“树根样”联接,直接联接和细胞内联接。运动可引起心肌间质胶原网络结构的重塑,一般运动负荷可使心肌与间质胶原网络同步增长,以适应心肌细胞肥大收缩力增加从而保证肌束间及心肌细胞间力的传递;运动超负荷可使心肌束间、心肌细胞间以及小动脉和毛细血管间不同类型胶原大量蓄积增生,导致心脏的僵硬度增加,舒缩功能降低。

Remodeling of intermyocardial collagen network (ICN) in SD rat models was observed by using scanning electron microscopy under conditions of different exercise intensity. The results showed that ICN formed a spatial three-dimensional structure consisting of collagenous fiber connection among myocardial, capillary and endocardium, which extensively distributed in four patterns of 'lattice', 'root ','shortcut', and 'intracellular'. Exercise could lead to remodeling of ICN, of which normal exercise load might lead to proportional increase of cardiac and ICN, adapting oneself ot transmit of contractility between myocardial bundles and cardiac muscle cell(CMC) under conditions of myocardial hypertrophy; and exercise overload might lead to increase of a large number of different collagen among myocardial bundles, CMC, arteriole and capillary , that could lead to increase of stiffness and descent of systolic and diastolic function of heart.