氟西汀治疗54例恶性肿瘤伴抑郁/焦虑状态的临床分析

A Clinical Analysis of Fluoxetine Treatment for 54 Cases with Depressive/Anxiety Symptoms in Cancer Patient

[目的]观察氟西汀治疗恶性肿瘤伴焦虑/抑郁状态患者疗效及对提高生活质量的影响。[方法]诊断标准按中国精神障碍分类与第3版(CCMD-3);用汉密尔顿焦虑量表(HAMA-14)和抑郁量表(HAMD-24)对诊断癌症相关性抑郁患者进行评分,对轻中度抑郁状态患者口服氟西汀20～40mg/d,治疗8周;WHO生活质量评定量表(WHO-QOL)评价生活质量改善情况,副反应量表(TESS)及相关实验室检查评价其安全性。[结果]治疗2w末,各量表评分较治疗前均有改善;治疗4～6w末各评分与治疗前有差异性显著(P<0.01);治疗8w末有效率分别为92.4%及96.3%;生活质量显著改善;不良反应均较轻微,无需特殊处理。[结论]部分肿瘤患者存在焦虑和抑郁状态,氟西汀抗抑郁治疗疗效显著。

[Objective] To study the effect and reliability of fluoxetine on depression and symptoms in cancer patient,and to assess the overall quality of life before and after treatment.[Methods]We treated 54 cancer patients with depression by Fluxetine for 8 w,at the same time,evaluated their emotion state,change of quality of life and the adverse effect with HAMD,HAMA,TESS and laboratory tests.[Results]After 8 w,patients’ scores of anxiety and depression decreased significantly from the baseline,effective rates were 82.4% and 96.3% respectively.3 domains of quality of life (physiology,psychology and independence) became much better than those of baseline.The side effect of fluxetine was small.[Conclusion]This study shows that fluoxetine can reduce the depression and anxiety symptoms in cancer patients.