ADRs监测的意义及方法

The Significance and Treatments of Adverse Drug Reaction Monitoring

医药界在60年代从几起震惊世界的药害事件中清醒地认识到药物不良反应（ADRs）对人类严重的危害，从而积极寻找预防ADRs途径与方法．本文介绍了ADRs监测报告方法的建立及发展，着重对自发呈报系统、医院集中监测系统、回顾性监测、前瞻性监测、病例对照研究、队列研究、记录联结、记录应用及病人参与上市后新药ANRs监测等方法进行了探讨，并提出ANRs因果关系判断的方法．旨在使广大基层医疗机构对ADRs监测的意义及方法有所了解，以便开展ADRs监测呈报工作，杜绝或减少ADRs的发生．

This article reviewed the significame and treatments of ADR(adverse drug reaction)monitoring. The main issues covered included 1 ) spontaneous reporting; 2)intensive hospital monitoring; 3 )retrospective survey monitoring; 4) look ahead monitoring; 5 ) case-control studies; 6) cohortstudies; 7)patient-initiated postmarketing surveillance: 8)judgement of ADR.