剧烈运动与训练诱发体内产生免疫抑制蛋白的初步研究

Study on the Immune Suppressive Protein Induced by Strenuous Exercise and Training

免疫抑制蛋白是在应激情况下体内出现的一种大分子蛋白,可抑制免疫功能,它是否参与了运动与免疫的调节?研究结果表明,持续的大运动量训练可使运动员血清出现免疫抑制蛋白,其分子量为140KD;1次急性超负荷游泳后小鼠血清内出现大分子量的免疫抑制因子,其分子量亦为140KD。说明免疫抑制蛋白在运动与免疫的调节中发挥着作用,提示在运动与免疫的调节中,存在着不同于神经内分泌调节机制的另一途径,即免疫抑制蛋白途径。

Immune suppressive protein, a big molecular protein, appears in serum at stress and can repress immune functions. The purpose of this study was to discuss the immuno-modulation role of immune suppressive protein in exercise. The results showed that prolonged heavy training led to immune suppressive protein in athletes' serum with molecular weight 140KD, and acute overload swimming until exhaustion induced to immune suppressive factor in mice's serum with molecular weight also 140KD. These suggested that there existed another way of accommodating immune function in exercise, the way of immune suppressive protein, which was different from the mechanism of neuro - endocrine regulation.