青蒿琥酯活性代谢产物双氢青蒿素的牛体代谢动力学

Pharmacokinetics of dihydroartemisnine of the active metabolite of artesunate in cows and cattle

健康奶牛与黄牛各 5头 ,分别单剂量静注 5mg/kg和 10mg/kg青蒿琥酯 ,用TLC法测定青蒿琥酯的活性代谢产物双氢青蒿素在牛血中的浓度。经统计矩方法计算分析双氢青蒿素的主要药动学参数 。

Dihydroartemisinine(DHA) is the active metabolite of artesunate(AS), which is effective in the (treatment) of theileriosis, babesiosis and cocoidiosis in veterinary practice. Artesunate was administered intra-(venously) at the doses of 5 and 10 mg per kg body weight for 5 cows and 5 cattle,respectively. The concentration of DHA in plasma was determined by TLC method developed in our laboratory. The pharmacokinetic parameters of DHA in cows and cattle were analyzed by statistical moment method and compared with the pharmacokinetic (parameters) of AS.