猪胆汁酸的药理作用研究(Ⅱ)——猪胆汁酸镇咳作用的初步观察

PHARMCEUTICAL STUDY OF SWINE'S BILE ACID( Ⅱ ) -OBSERVATION ON THE ANTITUSSIVE EFFECT OF THE SWINE'S BILE ACID

本文利用提取胆红素后的猪胆汁废液所制备的猪胆汁酸,作对SO_2诱发咳嗽的正常NIH系小白鼠镇咳效果观察。结果表明;猪胆汁中的胆汁酸对SO_2诱发咳嗽的小白鼠具有延长诱发咳嗽潜伏期和减少单位时间内咳嗽次数的效果。当口服15mg/kg时,诱发咳嗽的潜伏时间平均延缓6秒以上,P<0.01,与中成药蛇胆川贝散相一致;单位时间的咳嗽次数减少43％以上,P<0.01,优于蛇胆川贝散的效果。提示猪胆汁酸与贝母、桔梗等配伍时,对延长潜伏期具有协同作用。

When the swine's bile acid, made from the waste liquid of swine's bile after bilirubin is extracted, is used as an antitussive medicine to treat the mice's cough induced by SO2 the following result is recorded: The swine's bile acid is effective in prolongating the cough latency and decreasing the cough frequency per unit time. When 15mg/kg of its dosage is taken orally, the average latency prolongation is above six seconds. P<0.01, Compatible with 'SHEDANCHUANBEISAN' the cough frequency is reduced by more than 43% per unit time. P<0.01 is better than 'SHEDANCHUANBEISAN' . When the swine's bile acid is used together with Fritillaria cirrhosa. Platycodon grandiflerum and etc, a joint action is effected though its prolongation of the latency.