卡前列素氨丁三醇与米索前列醇在预防前置胎盘产后出血中的临床价值

Hemabate with misoprostol clinical value in preventing maternal placenta previa postpartum hemorrhage

目的观察卡前列素氨丁三醇和米索前列醇在预防前置胎盘产后出血中的临床效果。方法选择在本院行剖宫产手术的前置胎盘孕妇70例,随机分为观察组和对照组,各35例。其中观察组35例采用子宫体注射卡前列素氨丁三醇250μg,对照组采用子宫体注射缩宫素20 U并米索前列醇400μg术后塞肛,两组同时均给予缩宫素20 U静脉点滴维持。比较两组产妇产后出血率、产后2小时及24小时平均出血量,同时观察有无胃肠道不良反应。结果对照组产妇产后出血率为74.3%(16例),产后2小时平均出血量为(433.57±83.7)ml,产后24小时平均出血量为(507.59±80.3)ml;观察组产妇产后出血率为14.3%(5例),产后2小时平均出血量为(271.23±50.4)ml,产后24小时平均出血量为(381.76±78.5)ml,观察组产妇产后2小时及24小时的出血量较对照组明显减少,经统计分析两组间数据比较差异具有显著性(P<0.05);两组间不良反应发生率差异无显著性(P>0.05)。结论卡前列素氨丁三醇预防前置胎盘产后出血疗效优于米索前列醇,建议临床推广应用。

Objective To observe the clinical effect of hemabate and misoprostol for preventing postpartum hemorrhage after cesarean section of pregnant women with placenta previa. Methods Selected 70 patients of cesarean section with placenta previa and andomly divided into two groups:treatment group and control group. Control group was injected oxytocin 20 U into their uterine corpus immediately after cesarean section and misoprostol 0.4 mg po, treatment group was injected hemabate 250 μg, then the two groups all were injected oxytocin 20 U by intravenous drip continuously. Then compared the bleeding rate,the bleeding amounts of 2 hours and 24 hours after operation. Results The control group’s bleeding rate was 74.3%, the bleeding amounts of 2 hours was (433.57±83.7) ml and 24 hours was (507.59±80.3) ml;The treatment group’s bleeding rate was 14.3%, the bleeding amounts of 2 hours was (271.23±50.4) ml and 24 hours was (381.76±78.5) ml. The data is statistically signiifcant. Conclusion Hemabate is more effective than misoprostol for preventing postpartum hemorrhage after cesarean section of women with placenta previa.