期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Skp2基因的研究进展 被引量：1

Research Progress in Skp2 Gene
下载PDF
导出
摘要 Skp2被称为S期激酶相关蛋白,属于F-box蛋白家族成员,在蛋白泛素化降解过程中可作为SCF-Skp2复合物的重要成分起识别底物蛋白的作用,主要通过降解细胞周期调节蛋白介导细胞周期调控和细胞增殖。为更全面地了解Skp2的研究进展及开展其在动物科学与医学领域的研究,从Skp2基因的结构、功能、与人类肿瘤致病机理、转录调控和启动子方面的关系进行了综述。 Skp2,called S-phase kinase-associated protein 2,belongs to a member of F-box protein family.It plays a role as an important component of SCF-Skp2 compound for recognizing substrate protein in ubiquitin-protein degradation process.It mainly mediates cell cycle regulation and cell proliferation by degrading cyclins.In order to roundly understand research progress in Skp2 and develop study on animal science and veterinary medicine field,this review on Skp2 gene describes its structure,function,pathopoiesis mechanism in human tumor,transcriptional control and promoter.
作者 李勇 彭克美 李奎
机构地区 江西农业大学动物科技学院 华中农业大学动物科学动物医学院 中国农业科学院北京畜牧兽医研究所
出处 《湖北农业科学》 北大核心 2013年第3期502-507,共6页 Hubei Agricultural Sciences
基金 国家自然科学基金项目(30571330) 江西省科技支撑计划项目[赣财教(2007)173号] 江西省农业厅项目 江西农业大学博士创新研究基金项目
关键词 SKP2基因 功能 转录调控 肿瘤 启动子 Skp2 gene function transcriptional control tumor promoter
分类号 S [农业科学]
  • 相关文献

参考文献38

  • 1BASHIR T,DORRELLO N V,AMADOR V,et al.Controlof the SCF (Skp2-Cksl)ubiquitin ligase by the APCl C (Cdhl)ubiquitin ligaseNature,2004.
  • 2Hung WC,Tseng WL,Shiea J,et al.Skp2overexpression increases the expres-sion of MMP-2and MMP-9and invasion of lung cancer cellsCancer Letters,2010.
  • 3Huang H,Regan KM,Wang F,Wang D,Smith DI,van Deursen JM,Tindall DJ.Skp2 inhibits FOXOl in tumor suppression through ubiquitin-mediated degradationProceedings of the National Academy of Sciences of the United States of America,2005.
  • 4Hector Boix-Perales,Ian Horan,Helen Wise,Horng-Ru Lin,Li-Chiou Chuang,P Renee Yew,Anna Philpott.The E3 ubiquitin ligase skp2 regulates neural differentiation independent from the cell cycleNeural Development,2007.
  • 5Wu Y J,Sala-Newby G B,Shu K T,et al.S-phase kinase-associated protein-2 (Skp2)promotes vascular smooth muscle cell proliferation and neointima formation in vivoJournal of Vascular Surgery,2009.
  • 6Imaki H,Nakayama K,Delehouzee S,et al.Cell cycle-dependent regulation of the Skp2 promoter by GA-binding proteinCancer Research,2003.
  • 7李倩,李英勇.妇科肿瘤中Skp2的研究进展[J].国外医学（妇产科学分册）,2007,34(6):409-412. 被引量：1
  • 8Carrano AC,Eytan E,Hershko A,et al.SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27Nature Cell Biology,1999.
  • 9Gstaiger M,Jordan R,Lim M,et al.Skp2 is oncogenic and overexpressed in human cancersProceedings of the National Academy of Sciences of the United States of America,2001.
  • 10Demetrick D J,Zhang H,Beach D H,et al.Chromosomal mapping of the genes for the human CDK2 / cyclinA-associated proteins p1 9 (SKP1 AandSKP1 B) and p4 5 (SKP2 )Cytogenetics and Cell Genetics,1996.

二级参考文献22

  • 1Xiu-Mei Ma Ying Liu Jian-Wen Guo Jiang-Hui Liu Lian-Fu Zuo.Relation of overexpression of S phase kinase-associated protein 2 with reduced expression of p27 and PTEN in human gastric carcinoma[J].World Journal of Gastroenterology,2005,11(42):6716-6721. 被引量：20
  • 2Yi FU,Li-Ying WANG,Yu-Long LIANG,Jia-Wei JIN,Zheng-Yu FANG,Xi-Liang ZHA.Integrin βA Upregulates p27 Protein Amount at the Post-translational Level in Human Hepatocellular Carcinoma Cell Line SMMC-7721[J].Acta Biochimica et Biophysica Sinica,2006,38(8):523-530. 被引量：4
  • 3OeSalle LM, Pagano M. Regulation of G1 to S transition by the ubiquitin pathway[J]. FEBS Lett, 2001, 490(3): 179-189.
  • 4Zhang H, Kobayashi R, Galaktionov K, et al. p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase[J]. Cell, 1995, 82(6): 915-925.
  • 5Sehulman BA, Csrrano AC, Jeffrey PD, et al. Insights into SCF ubiquitin ligases from the structure ofthe Skp1-Skp2 complex [J]. Nature, 2000, 408(6810): 381-386.
  • 6Zheng N, Sehuhnan BA, Song L, et al. Structure of the Cull-Rbx1- Skp1-F box Skp2 SCF ubiquitin ligase complex[J]. Nature, 2002, 416(6882): 703-709.
  • 7Ungermannova D, C, ao Y, Liu X. Ubiquitination of p27Kip1 requires physical interaction with cyclin E and probable phosphate recognition by Skp2 [J]. J Biol Chem, 2005, 280 (34): 30301- 30309.
  • 8Xu S, Abbasian M, Patel P, et al. Substrate recognition and ubiquitination of SCFSkp2/Cks1 ubiquitin-protein isopeptide ligase [J]. J Biol Chem, 2007, 282(21 ): 15462-15470.
  • 9Wang W, Nacusi L, Sheaff R J, et al. Ubiquitination of p21Cip1/ WAF1 by SCFSkp2: substrate requirement and ubiquitination site selection[J]. Biochemistry, 2005, 44(44): 14553-14564.
  • 10Joanson JH, Gavrilova N, Wu M, et al. Regulation of SCF (SKP2) Ubiquitin E3 Ligase Assembly and p27 (KIP1) Proteolysis by the PTEN Pat hway and Cyclin D1 [J]. Cell Cycle, 2007, 6 (8): 951-961.

共引文献1

同被引文献2

引证文献1

湖北农业科学
2013年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部