指甲油中18种邻苯二甲酸酯类化合物的GC-MS法测定

Determination of 18 Phthalates in Nail Polish by GC-MS

目的建立指甲油中邻苯二甲酸酯类化合物的测定方法。方法采用GC-MS联用法检测指甲油中邻苯二甲酸酯类化合物,检测方式为SCAN和SIM。结果实验条件下,18种邻苯二甲酸酯类化合物能很好分离检测,各组分的检出限均大于0.2μg/g,线性范围均在0.2～4μg之间,相关系数均大于0.998,相对标准偏差RSD均小于10%,加标回收率在85%～101%之间。结论本法操作简便、准确、分离效果好,对色谱柱和仪器污染小,进样残留少,可同时测定指甲油中的18种邻苯二甲酸酯类化合物。

Objectives To establish a GC-MS method for simultaneous determinations of 18 kinds of phthalates in nail polish.Methods Phthalates were extracted with methanol,the analysis was performed by GC-MS SCAN and SIM using DB-5MS column(30 m×0.25 mm×0.25 μm).Results 18 phthalates could be completely separated under the condition of GC-MS.Each component can be detected greater than 0.2 μg/g.The linear range was 0.2~4 μg,relative coefficient was more than 0.998,RSD was less than 10%,and average recovery was 85%~101%.Conclusions This detection method is simple,accurate,reproducible,and well separated.The column and instrument are less polluted.The feeder has few residues.18 phthalates esters could be simultaneously determined in nail polish.