康艾注射液对乳腺癌患者血清血管内皮生长因子水平的影响

A preliminary study of effect of Kang'ai injection on serum vascular endothelial growth factor in breast cancer

目的观察康艾注射液对乳腺癌血清血管内皮生长因子(s-VEGF)的影响及抗肿瘤血管生成的作用。方法应用酶联免疫吸附法检测21例康艾注射液加化疗患者(实验组)和21例单纯化疗患者(对照组)治疗前后血清s-VEGF水平。结果治疗前乳腺癌s-VEGF与患者年龄、肿瘤大小、组织学分级无关,与患者淋巴结转移、临床分期有关(P<0.05)。实验组治疗后s-VEGF水平为(210.05±47.49)pg/mL,明显低于治疗前(P<0.05);对照组治疗后s-VEGF水平为(252.62±56.33)pg/mL,与治疗前无明显差异;实验组治疗后明显低于对照组治疗后(P<0.05)。结论康艾注射液可以降低乳腺癌患者的s-VEGF水平,有利于抑制肿瘤的发展。

Objective To observe the effect of Kang’ai injection on serum vascular endothelial growth factor(s-VEGF) of patients with breast cancer and study the effect of Kang’ai injection on anti-tumor antigenic therapy.Methods The s-VEGF concentrations of 21 patients treated by chemotherapy combined with Kang’ai injection(test group) and 21 patients,treated by chemotherapy(control group) with breast cancer were detected by enzyme-linked immunosorbent assay before and after treatment.Results The serum level of s-VEGF in patients with breast cancer was significantly related to lymph node metastasis and clinical stage(P&lt;0.05),but was not related to age,histological grade,size of the tumors.In test group,the serum level of s-VEGF after treatment was(210.05±47.49) pg/mL,which was obviously lower than that before treatment(P&lt;0.05).In control group,the serum level of s-VEGF was(252.62±56.33)pg/mL,which showed no significant difference compared with pretherapy.The serum level of s-VEGF after treatment in test group was obviously lower than that of in control group(P&lt;0.05).Conclusion Kang’ai injection can obviously reduce the level of s-VEGF in patients with breast cancer,and may be beneficial in inhibiting tumor growth and metastasis.