摘要
目前生产阿贝卡星的反应后处理步骤较多,影响产率,而且生产过程中原料成本很高,限制了阿贝卡星的广泛应用。本课题组的目的就是要以2-甲酰巯基苯并噻唑作为保护基团,来简化合成阿贝卡星的反应步骤,改善后处理条件,提高产率,使阿贝卡星作为一种优良的广谱抗菌药应用更广泛。
However,complicated procedures,low yield and high cost of raw material made it impossible for Arbekacin to be utilized widely.Herein,we report the significandy to 2-fomiyl mercaptobenzothiazole as protecting group to improved synthesis of dibekacin and Arbekacin.which simplified the reaction route,improved the yield,reduced the cost significandy and enabled the wild use of Arbekacin as broad-spectrum antibiotics.
