摘要
慢性脑低灌注诱导神经细胞变性,是导致患者认知功能障碍和社会能力低下的重要因素之一,脑血管疾病的病理发生有密切的关系。内源性大麻毒素(ECS)包括G蛋白耦联受体CB1、CB2,内源性配基AEA、2-AG及其内源性配基失活系统AEA水解酶FAAH等,国内外研究表明ECS在中枢神经系统具有多种内源性生理性调节作用并介导哺乳动物的神经保护作用,其主要表现在受体水平、失活系统、免疫应答及突触可塑性等方面;现就内源性大麻素系统(ECS)对慢性脑低灌注患者认知功能障碍的调控作用作一综述。
Chronic cerebral hypoperfusion induced degeneration of nerve cells is one of the important factors in low social ability in patients with cognitive dysfunction,and is closely linked to pathology of neurodegenerative and cerebrovascular disease. Domestic and foreign researches on Endocannabinoid toxin ( ECS) including G protein-coupled receptor CB1,CB2,AEA,2-AG endogenous ligand and its endogenous ligand deactivation system AEA hydrolase FAAH have shown that ECS has a neuroprotective effect of endogenous physiological regulation mediated in mammalian central nervous system,which is mainly manifested in the receptor level,deactivation system,immune responses and synaptic plasticity and so on. This article is to review the endocannabinoid system ( ECS) effects on cognitive impairment in patients with chronic cerebral hypoperfusion.
出处
《外科研究与新技术》
2013年第1期41-44,共4页
Surgical Research and New Technique
基金
国家自然科学基金资助项目(81271212)
关键词
内源性大麻素系统
慢性脑低灌注
认知功能障碍
调控作用
Endocannabinoid system
Chronic cerebral hypoperfusion
Cognition dysfunction
Regulate and control effect
