复合维生素对体外受精女性血清及卵泡液中微量元素的影响

Effects of multivitamin/mineral supplementation on element levels in serum and follicular fluid of women undergoing in vitro fertilization

目的探讨复合维生素对体外受精(IVF)女性血清及卵泡液中微量元素的影响。方法选取行IVF女性60例,分为两组:受试组30例,口服复合维生素片60天。安慰剂组30例,口服安慰剂。同时选取25例健康女性作为对照组。分别测定三组血清铜、锌、铁、锰、钙的含量。同时测定IVF组卵泡中5种微量元素的含量。结果(1)血清中的铜、锌含量在IVF组明显低于对照组(P<0.05)。而在服用复合维生素组血清中的铜(P<0.05)、锌(P<0.01)、锰(P<0.05)的含量明显高于未服药组。(2)IVF服药组的卵泡液中铜(P<0.01)、锌(P<0.05)的水平明显高于未服药组。然而铁含量在IVF服药组中明显低于未服药组(P<0.001)。结论复合维生素的摄人可以平衡IVF女性血清及卵泡液中微量元素的水平。

Objectives The authors investigated effects of multivitamin/mineral supplementation on element levels in serum and follicular fluid of women undergoing IVF.Methods The authors recruited three groups of subjects in this study.The first group was used as an age-matched and nonpregnant control(n=25).Group 2(n=30)constituted the IVF group and women in the third group(n=30)who underwent IVF also received a multivitamin/mineral tablet daily for 60 days.Results(1)Serum zinc levels,and copper levels were lower in IVF patients than in controls(P<0.05).Serum zinc(P<0.01),copper(P<0.05)and magnesium(P<0.05)levels were higher in the multivitamin/mineral group than in the IVF group.(2)Follicular fluid copper(P<0.01)and zinc(P<0.05)levels were higher in the multivitamin/mineral group than in the IVF group although follicular fluid iron levels were lower in the multivitamin/mineral group than in the IVF group(P<0.001),Conclusion Multivitamin/mineral supplementation in serum and follicular fluid of women undergoing IVF might normalize the trace element levels.