生物标志物在颅脑损伤中的应用

Biomarkers for the clinical diagnosis in traumatic brain injury

颅脑损伤(traumatic brain injury,TBI)是世界性的健康难题,是成年人致死致残的主要原因之一。虽然通过预防教育,增加安全装置的使用率及对TBI的治疗已经显著的增加了存活的可能性,但仍有必要采取可靠的方法来诊断TBI及鉴别诊断TBI类型,了解其继发性的病理改变及预测预后。现有的一系列蛋白质或脂质分子作为TBI脑损伤可行的生物标志物与TBI预后直接相关,但预测性的生物标志物对于TBI更为重要。

Traumatic brain injury (TBi) is recognized as the leading cause of mortality and morbidity in young adults around the world.The important factors determining prognosis of TBi patients are severity of the primary brain injury and degree of subsequent secondary damage.The ability of biomarkers to tease out and identify focal and diffuse brain injury or the potential to diagnose intracranial hypertension would make these markers extremely valuable.