体外冲击波碎石治疗输尿管结石后坦索罗辛辅助排石的效果观察

Clinical adjunctive effects of tamsulosin on patients with lower ureteral stones after extracorporeal shock wave lithotripsy

目的评价坦索罗辛在体外冲击波碎石(ESWL)治疗输尿管下段结石后的辅助排石疗效。方法选择已行ESWL治疗的输尿管下段结石62例,随机分为实验组和对照组,每组各31例。两组患者均口服左氧氟沙星每日0.4 g、中成药肾石通丸每日4 g,实验组加服坦索罗辛每日0.4 mg,随访观察2周。结果排石率对照组为61.3%(19/31),实验组为87.1%(27/31),两组比较具有显著性差异(2χ=5.391,P<0.05)。肾绞痛发生率对照组为25.8%(8/31),实验组为6.4%(2/31),两组结果比较具有显著性差异(2χ=4.292,P<0.05)。结论坦索罗辛能有效提高输尿管下段结石ESWL后的排石率,减少排石过程中肾绞痛的发生。

Objective To evaluate the clinical adjunctive effects of tamsulosin on patients with lower ureteral stones after extracorporeal shock wave lithotripsy(ESWL).Methods 62 patients with lower ureteral stones after ESWL were randomly divided into the control group and the experimental group(31 cases in each group).Both groups accepted levofloxacin(0.4g/d) and the traditional Chinese medicine pellet Shenshitong(4g/d).The experimental group accepted tamsulosin(0.4mg/d).All patients were followed up for 2 weeks.Results The rate of expulsion of the stones was 61.3%(19/31) of control group and 87.1%(27/31) of experimental group.The ratio of renal colic was 25.8.3%(8/31) of control group and 6.4%(2/31) of experimental group.The differences of result between two groups were statistically significance(χ2=4.292,P<0.05).Conclusion Tamsulosin has an adjunctive effects for the treatment of lower ureteral stones and can significantly reduce the rate of renal colic after ESWL.