摘要
目的 探讨万爽力(曲美他嗪)对稳定性冠心病患者内皮细胞功能的影响。方法 对61例稳定性冠心病患者采用随机、单盲、对照的方法分为两组,一组为常规治疗组(n=30),另一组为万爽力组(n=31),连续治疗8周。治疗前后静脉抽血,采用放射免疫法测定血浆中的肾上腺髓质素(ADM)及内皮素-1(ET-1)的浓度。结果 万爽力组治疗后ADM浓度明显上升(P<0.05),同时ET-1浓度明显下降(P<0.05),且与常规治疗组比较有显著差异(P<0.05)。结论 万爽力可改善稳定性冠心病中层得内皮细胞功能。
Objective: To observe the effect of trimetazidine on the vascular endothelial function in stale coro-nary artery disease. Methods: 61 patients with stale coronary artery were divided into two groups by using arandomized, control and single blind method,trimetazidine group(n=31) and routine treatment group(n=30),with a treatment course of 8 weeks for both groups.The concentration of plasma endothelin(ET-1) andadrenomeeduloium(ADM) were measured by radioimmunoassay in 61 cases before and were improved obviously.There was a singnificant difference between trimetazidine group and routine treatment group (p<0.05) .onclusion:Trimetazidine can improve the vascular endothelial function of patients with stale coronary arterydisease.[
出处
《中国医学生物技术应用》
2004年第1期49-51,共3页
The Chinese Academic Medical Magazine of Organisms
关键词
万爽力
冠心病
内皮功能
trimetazidine
coronary artery disease
endothelial function
