摘要
目的 评价坎地沙坦酯治疗原发性轻中度高血压的临床疗效和安全性。方法 选择48例轻中度原发性高血压病人通过2周导入期后随机分入试验组和对照组各24例,按双盲、平行临床药理试验方法分别给予坎地沙坦酯和氯沙坦治疗。治疗4周后如不能有效控制血压,则将用药剂量加倍并维持到第8周末。检测患者治疗前和治疗后不同时间的血压、心率以及血常规、尿常规、肝、肾功能。记录用药期间可能发生的不良事件。结果 试验组和对照组降压显效率均为100%,治疗后2周末收缩压(SBP)和舒张压(DBP)均已明显降低。此后血压继续下降,与用药治疗前相比,用药8周末,试验组和对照组SBP分别下降20.3mmHg和16.4mmHg,DBP分别下降16.8 mmHg和16.1 mmHg。试验组1例病人服药期间出现中度头痛,1例病人感轻度胸闷和腹胀。两组血常规、肝、肾功能均正常。结论 坎地沙坦酯治疗原发性轻中度高血压疗效良好、服用安全。
Objective To evaluate efficacy and safety of Candesartan cilexetil in treatment of patients withmild and moderate essential hypertension.Method 48 patients with mild and moderate essential hypertensionwere randomized and double-blind divided into Candesartan group(N=24) and Losartan group(N=24) after theyhad finished the induction treatment.If the blood pressure was still over standard,the doseage of drugs usedwere doubled from the 5th week till the 8th .Blood pressure,heart rate and side effects were investigated every2 weeks.Before and after trial laboratory test (liver and renal function,blood and urine routine) were performed.Results The antihypertensive efficacy rate of the two drugs were 100%.The systolic blood pressure(SBP)and(Continued to page 62)diastolic blood pressure(DBP)in two groups decreased significantly after the study being taken for two weeks.And from then on,the SBP and DBP in two groups continued decline.Compared with before the trial the SBPand DBP decreased 20.3mmHg and 16.8mmHg,respectively, in Candesartan group,and in Losartan group theSBP and DBP decreased 16.4mmHg and 16.1mmHg,separately,on the end of this trial. Except one patientappearing moderate headache,one appearing mild chest discomfort and abdominal distension,the others hadno discomfortable feeling.All laboratory tests were normal.Conclusion Candesartan cilexetil like Losartan maybe used in the antihypertension treatment of patients with mild and moderate essential hypertension effec-tively and safely.[
出处
《中国医学生物技术应用》
2004年第1期52-56,62,共6页
The Chinese Academic Medical Magazine of Organisms
