摘要
目的研究养心氏片(YXS)对环孢素A(CsA)血药浓度及其药动学参数的影响。方法采用反相高效液相色谱法(RP-HPLC)对单用CsA及YXS与CsA合用后家兔体内CsA全血浓度进行测定,并对两组药动学参数进行统计学处理。结果YXS可使CsA的Cmax增大、T1/2β减小,差异有显著性(P<0.05),其余药动学参数无显著变化。结论养心氏片可使CsA的峰浓度增高、消除速率加快。
Objective To study the effects of YangXinShi Pian (YXS) on pharmacokinetics of cyclosporine A(CsA).Methods Six healthy rabbits took CsA 30mgkg-1 alone or in combination with YXS 25mgkg-1, the CsA concentra-tion in whole blood were determined with RP-HPLC. Data were alalyzed with 3P97 program. Results The bloodconcentration-time curve was fitted to open 2-compartment model, the Cmax, T1/2βof CsA alone(1 259.7976.34,2.590.22) and CsA+YXS(1 799.3286.54, 1.710.15) were significant difference(P<0.05).Conclusion YXS can in-crease the peak plasma concentration and elimination rate of CsA.
出处
《中国医学生物技术应用》
2002年第4期52-53,73,共3页
The Chinese Academic Medical Magazine of Organisms
