大剂量螺内酯方案在原发性醛固酮增多症术前准备中的应用研究

Evaluation of High-Dose Spironolactone in the Preoperative Preparation of Primary Aldosteronism

目的探讨大剂量螺内酯方案在原发性醛固酮增多症患者术前准备降压治疗中的有效性及安全性。方法选取山东省立医院泌尿微创中心2009年6月至2011年6月收治的42例合并高血压病的原发性醛固酮增多症患者。以大剂量螺内酯控制患者术前血压至稳定,观察患者术前血压控制效果及服药前后肝肾功能变化及药物不良反应。结果所有患者行大剂量螺内酯治疗均术前血压达到稳定,螺内酯每日口服3次,240～540mg/d,平均使用剂量为361mg/d;血压控制至稳定时间3～6天(平均3.6天)。除1例患者术前1日复查血清肌酐水平略高于正常外,所有患者术前复查血肝肾功能均无异常升高。无其他药物不良反应发生。结论大剂量螺内酯在原发性醛固酮增多症患者术前血压控制应用上是安全有效的。

Objective To research the efficiency and safety of high-dose spironolactone in the preoperative preparation of patients with primary aldosteronism. Methods Forty-two primary aldosteronism patients were enrolled in this study from June 2009 to June 2011. Those patients were applied with high-dose spironolactone to control their high blood pressure.Results Under high-dose spironolactone, all the patients' blood pressure were controlled. Spironolactone were given three times a day, 240~540 mg(mean 361 mg) per day.The duration time from beginning to normal blood pressure was 3~6 days (mean 3.6 days). On the day before operation, only 1 patient had higher blood creatinine value. The laboratory examination findings of the others were normal. Conclusions High-dose spironolactone in the preoperative preparation of primary aldosteronism is efficient and safe.