摘要
To evaluate the effects of leucocyte-depleting filtration on systemic inflammatory response in patients undergoing valve surgery.Methods Fifty-two patients underwent elective mitral valve or mitral and aortic valves replacement surgery in this study.Patients were randomly divided into two groups.Each group (n=26) was placed on the same cardiopulmonary bypass (CPB) circuit except for the arterial line filter.One group of patients (CG) used the TERUMO ordinary arterial line filter as a control,and the Pall LG-6 leucocyte-depleting arterial line filter and TERUMO ordinary arterial line filter were incorporated into the arterial line of extracorporeal circuit in a parallel way in the EG.The leukocyte-depleting filters were used from 5-10 minutes before aortic cross clamp release to the end of CPB.Intra- and postoperative variables consist of leucocyte counts,serum levels of cytokines and complement C3,body temperature and the usage of antibiotics.Statistical analysis with indepent-samples t-tests,paired-samples t-test,correlate and chi-square (SPSS11.5) was performed on all data to test for significan differences.A P value of <0.05 was considered significant.Results The counts of leucocyte,neutrophil and monocyte were reduced significantly before cardiopulmonary reperfusion in the patients undergoing leucocyte-depleting filtration.Serum levels of IL-6 between the two groups were similar at all time points.Serum levels of IL-8 were significantly elevated in the patients undergoing leucocyte depletion at pre-decrossclamping and 15 minutes reperfusion (P<0.01 and <0.05).Serum level of TNFα was significantly elevated (P<0.05) in the EG at pre-decrossclamping compared to the CG.No significant differences in serum levels of complement C3 were detected between the two groups at all time points observed.No difference in the usage of antibiotics between the two groups.Conclusion Leucocyte depletion filtration before and during reperfusion did not affect inflammatory parameters.14 refs.1 tab.
To evaluate the effects of leucocyte-depleting filtration on systemic inflammatory response in patients undergoing valve surgery.Methods Fifty-two patients underwent elective mitral valve or mitral and aortic valves replacement surgery in this study.Patients were randomly divided into two groups.Each group (n=26) was placed on the same cardiopulmonary bypass (CPB) circuit except for the arterial line filter.One group of patients (CG) used the TERUMO ordinary arterial line filter as a control,and the Pall LG-6 leucocyte-depleting arterial line filter and TERUMO ordinary arterial line filter were incorporated into the arterial line of extracorporeal circuit in a parallel way in the EG.The leukocyte-depleting filters were used from 5-10 minutes before aortic cross clamp release to the end of CPB.Intra- and postoperative variables consist of leucocyte counts,serum levels of cytokines and complement C3,body temperature and the usage of antibiotics.Statistical analysis with indepent-samples t-tests,paired-samples t-test,correlate and chi-square (SPSS11.5) was performed on all data to test for significan differences.A P value of <0.05 was considered significant.Results The counts of leucocyte,neutrophil and monocyte were reduced significantly before cardiopulmonary reperfusion in the patients undergoing leucocyte-depleting filtration.Serum levels of IL-6 between the two groups were similar at all time points.Serum levels of IL-8 were significantly elevated in the patients undergoing leucocyte depletion at pre-decrossclamping and 15 minutes reperfusion (P<0.01 and <0.05).Serum level of TNFα was significantly elevated (P<0.05) in the EG at pre-decrossclamping compared to the CG.No significant differences in serum levels of complement C3 were detected between the two groups at all time points observed.No difference in the usage of antibiotics between the two groups.Conclusion Leucocyte depletion filtration before and during reperfusion did not affect inflammatory parameters.14 refs.1 tab.
出处
《外科研究与新技术》
2005年第3期195-196,共2页
Surgical Research and New Technique
