期刊文献+

The influence of α_1 adrenoceptor for glucose transporting in different blood supply states myocardium

The influence of α_1 adrenoceptor for glucose transporting in different blood supply states myocardium
下载PDF
导出
摘要 Objective To study the mechanism of glucose transporting by the way of in different blood state myocardium.Methods The expression of GLUT4、 GLUT1 was dectected with Western blotting analysis.Results GLUT4、GLUT1 was increased when phenylephrine was used before ischemia. During ischemia,GLUT4、GLUT1 was increased. Phenylephrine given during repefusin increased GLUT4、GLUT1.Prazosin given during ischemia,GLUT4、GLUT1 was reduced. During reperfusion,GLUT4、GLUT1 was decreased.Conclusion Changing the expression of GLUT4、 GLUT1,adjustting transporting of glucose,controlling glucose transport in different states of cardiac muscle cell by α1-adrenoceptors. Objective To study the mechanism of glucose transporting by the way of in different blood state myocardium.Methods The expression of GLUT4、 GLUT1 was dectected with Western blotting analysis.Results GLUT4、GLUT1 was increased when phenylephrine was used before ischemia. During ischemia,GLUT4、GLUT1 was increased. Phenylephrine given during repefusin increased GLUT4、GLUT1.Prazosin given during ischemia,GLUT4、GLUT1 was reduced. During reperfusion,GLUT4、GLUT1 was decreased.Conclusion Changing the expression of GLUT4、 GLUT1,adjustting transporting of glucose,controlling glucose transport in different states of cardiac muscle cell by α_1-adrenoceptors.
作者 方宏
出处 《外科研究与新技术》 2005年第4期306-310,共5页 Surgical Research and New Technique
关键词 α<sub>1</sub>-Adrenoceptors Ischemia/ Reperfusionheart transplantation cardiac ALLOGRAFT vasculopathy iNOSmRNA α_1-Adrenoceptors Ischemia/ Reperfusionheart transplantation cardiac allograft vasculopathy,iNOSmRNA
  • 相关文献

参考文献10

  • 1Weiss JN,Lamp ST.Glycolysis preferentially inhibits ATP-sensitive K+channelsinisolated guinea pig car- diac myocytes. Science . 1987
  • 2Loubani M,Galinanes M.alpha1 -Adrenoceptors dur- ing si mulated ischemia and reoxygenation of the human myocardium:effect of the dose and ti me of administra- tion. Journal of Thoracic and Cardiovascular Surgery . 2001
  • 3Egert S,Nguyen N,Schwaiger M.Contribution of -A- drenergic andα-Adrenergic Sti mulation to Ischemia - Induced Glucose Transporter ( GLUT) 4 and GLUT1 Translocation in the Isolated Perfused Rat Heart. Circulation Research . 1999
  • 4McFalls EO,Murad B,LiowJS,et al.Glucose uptake and glycogenlevels areincreasedin pig heart after repet- itive ischemia. American Journal of Physiology Heart and Circulatory Physiology . 2002
  • 5Armstrong JS,Steinauer KK,French J,et al.Bcl -2 in- hibits apoptosisinduced by mitochondrial uncoupling but does not prevent mitochondrial transmembrane depolar- ization. Experimental Cell Research . 2001
  • 6Sellevold OF,Jynge P,Aarstad K.High performance liquid chromatography :a rapid isocratic method for de- termination of creatine compounds and adenine nu- cleotides in myocardial tissue. Journal of Molecular and Cellular Cardiology . 1986
  • 7Czech MP,Covera S.Signaling mechanisms that regu- late glucose transport. Journal of Biochemistry . 1999
  • 8Sun DQ,Nguyen N,DeGrado TR,et al.Ischemia in- duces translocation of the insulin -responsive glucose transporter GLUT4 to the plasma membrane of cardiac myocytes. Circulation . 1994
  • 9Lopaschuk GD,Stanley WC.Glucose metabolismin the ischemic heart. Circulation . 1997
  • 10Tardy -Cantalupi I,Moutessuit C,Papageorgiou I,et al.Effect of transient ischemia onthe expression of glu- cose transporters GLUT-1 and GLUT-4 in rat my- ocardium. Journal of Molecular and Cellular Cardiology . 1999

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部