摘要
Objective To investigate the expression of midkine (MK) and its relation with angiogenesis, biological features and prognosis of pancreatic carcinoma (PC). Methods MK expression and microvessel density (MVD) were determined in 52 cases of human PC with immunohistochemistry and results were compared with pathology. Results Mean MVD of PC was 64 ± 18 and positive expression of MK was detected in 38 cases (73%). The positive rate of MK was significantly lower in cases of without metastasis and at early clinical stage (stage Ⅰ - Ⅱ) than that with metastasis and at stage Ⅲ - Ⅳ. MVD was significantly higher in MK-positive PC than in MK-negative PC (P 【 0. 01). Follow-up showed that postoperative survival time was shorter in patients with positive expression of MK. Conclusion MK is closely related to angiogenesis PC. MK expression is one of the predictors for the biological behavior of PC. 4 refs, 1fig.
Objective To investigate the expression of midkine (MK) and its relation with angiogenesis, biological features and prognosis of pancreatic carcinoma (PC). Methods MK expression and microvessel density (MVD) were determined in 52 cases of human PC with immunohistochemistry and results were compared with pathology. Results Mean MVD of PC was 64 ± 18 and positive expression of MK was detected in 38 cases (73%). The positive rate of MK was significantly lower in cases of without metastasis and at early clinical stage (stage Ⅰ - Ⅱ) than that with metastasis and at stage Ⅲ - Ⅳ. MVD was significantly higher in MK-positive PC than in MK-negative PC (P < 0. 01). Follow-up showed that postoperative survival time was shorter in patients with positive expression of MK. Conclusion MK is closely related to angiogenesis PC. MK expression is one of the predictors for the biological behavior of PC. 4 refs, 1
fig.
出处
《外科研究与新技术》
2003年第2期75-75,共1页
Surgical Research and New Technique
