Expression of HSP90aaaaaa in hepatocellular carcinoma and its signiflcance

Objective To investigate the expression of HSP90α in human hepatocellular carcinoma (HCC) and explore its relation to biological behavior and prognosis of the tumor. Methods Immunohistochemical S - P method was used to detect the expression of HSP90α in liver tissue from 10 normal individuals and liver and juxtacancerous tissues from 40 patients with HCC. Results The expression rate of HSP90α was 10% ,52.5% and 72.5% in normal liver tissue,juxtacanerous tissue and HCC tissue,respectively. A significantly higher distribution of HSP90α expression in HCC tissue compared with juxtacancerous tissue and normal liver tissue was found (P 【 0. 05). HSP90α was markedly correlated to tumor differentiation and size (P 【0. 05) but not to tumor number (P 】 0. 05). Meanwhile,it was correlated with prognosis of HOC. The mean tumor-free survival time in HSP90α-negative patients was 38. 6 months while that in HSP90α-positive ones 25. 5 months. There was significant difference between these 2 groups of patients (

Objective To investigate the expression of HSP90α in human hepatocellular carcinoma (HCC) and explore its relation to biological behavior and prognosis of the tumor. Methods Immunohistochemical S - P method was used to detect the expression of HSP90α in liver tissue from 10 normal individuals and liver and juxtacancerous tissues from 40 patients with HCC. Results The expression rate of HSP90α was 10% ,52.5% and 72.5% in normal liver tissue,juxtacanerous tissue and HCC tissue,respectively. A significantly higher distribution of HSP90α expression in HCC tissue compared with juxtacancerous tissue and normal liver tissue was found (P < 0. 05). HSP90α was markedly correlated to tumor differentiation and size (P <0. 05) but not to tumor number (P >. 05). Meanwhile,it was correlated with prognosis of HOC. The mean tumor-free survival time in HSP90α-negative patients was 38. 6 months while that in HSP90α-positive ones 25. 5 months. There was significant difference between these 2 groups of patients ( P < 0. 05 ). Conclusion HSP90α is overexpressed in human HCC and can be used as an indicator to judge differentiation and prognosis of HCC. 9 refs,2 figs,1 tab.