摘要
Objective To investigate the cytokine genotypes of the renal transplantation recipients with or without acute rejections. Methods The cytokine genotypes of peripheral blood TNF-α, TNF-β IL-δ and IEM-γ in 89 kidney to allograft receipients were detected by using PCR method. According to the test, the occurrence of acute rejection was compared among the groups. Results TNF-α and INF-γ high producer genotype ( -308 GA and AA) showed a correlation with the high incidence of acute rejection to the HLA-DR mismatching recipients. Conclusion To detect the cytokines gene polymorphisms before operations can find the high-risk kidney receipients who may suffer from the acuteChina Medical Abstracts(Surgery) rejection. It’ s very helpful in guiding the individual use of immunosuppressants following the renal transplantation. 4 refs.
Objective To investigate the cytokine genotypes of the renal transplantation recipients with or without acute rejections. Methods The cytokine genotypes of peripheral blood TNF-α, TNF-β IL-δ and IEM-γ in 89 kidney to allograft receipients were detected by using PCR method. According to the test, the occurrence of acute rejection was compared among the groups. Results TNF-α and INF-γ high producer genotype ( -308 GA and AA) showed a correlation with the high incidence of acute rejection to the HLA-DR mismatching recipients. Conclusion To detect the cytokines gene polymorphisms before operations can find the high-risk kidney receipients who may suffer from the acute
China Medical Abstracts(Surgery) rejection. It' s very helpful in guiding the individual use of immunosuppressants following the renal transplantation. 4 refs.
出处
《外科研究与新技术》
2003年第2期134-135,共2页
Surgical Research and New Technique
