血浆纤维蛋白原、D-二聚体检测在肺部疾病的临床意义

The clinical significance of serum fibrinogen and d-dimer in diagnosis for lung diseases

目的探讨血浆纤维蛋白原(Fibrinogen,Fig)、D-二聚体(D-dimer)检测在肺部疾病中的临床意义。方法对236例住院治疗的肺炎、慢性阻塞性肺疾病、急性肺栓塞及肺癌患者的血浆Fig、D-dimer进行测定,分析比较血浆Fig、D-dimer水平的差异性。结果肺炎、慢性阻塞性肺疾病、急性肺栓塞及肺癌组的血浆Fig,D-dimer水平与对照组比较差异有统计学意义(P<0.05)。急性肺栓塞、肺癌组的d-dimer明显高于其他疾病组,差异有统计学意义(P<0.05)。肺癌组纤维蛋白原明显高于其他疾病组,差异有统计学意义(P<0.05)。结论肺炎、慢性阻塞性肺疾病、肺栓塞及肺癌都可引起凝血机制的异常,引起血浆纤维蛋白原及D-dimer水平的升高。纤维蛋白原及D二聚体对肺部疾病的诊断有一定临床价值。

Objective The aim of the study was to discovery the clinical significance of serum fibrinogen and d-dimer in diagnosis for lung diseases.Methods Two hundred and thirty-six serum samples were detected with fibrinogen and d-dimer in pneumonia group,chronic obstructive pulmonary disease group,acute pulmonary embolism group and pulmonary cancer group.The data of the fibrinogen and the d-dimer were compared among the four diseases.Results There were significant statistic difference with the fibrinogen and d-dimer among pneumonia group,chronic obstructive pulmonary disease group,acute pulmonary embolism group and pulmonary cancer group.The concentrations of d-dimer were significant higher in the acute pulmonary embolism group and pulmonary cancer group than that of the other groups.The concentrations of the fibrinogen were higher in the pulmonary cancer than that of the other groups.Conclusions Different pulmonary diseases may be related to the abnormal coagulation state.The fibrinogen and d-dimer may be useful for diagnosis the pulmonary diseases.