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Modulators affecting the immune dialogue between human immune and colon cancer cells 被引量:8

Modulators affecting the immune dialogue between human immune and colon cancer cells
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摘要 The link between chronic inflammation and colorectal cancer has been well established. The events proceeding along tumorigenesis are complicated and involve cells activated at the cancer microenvironment, tumor infiltrating polymorphonuclears, immune cells including lymphocyte subtypes and peripheral blood mononuclear cells(PBMC), as well as tumor-associated macrophages. The immune cells generate inflammatory cytokines, several of them playing a crucial role in tumorigenesis. Additional factors, such as gene expression regulated by cytokines, assembling of tumor growth- and transforming factors, accelerated angiogenesis, delayed apoptosis, contribute all to initiation, development and migration of tumor cells. Oxygen radical species originating from the inflammatory area promote cell mutation and cancer proliferation. Tumor cells may over-express pro-inflammatory mediators that in turn activate immune cells for inflammatory cytokines production. Consequently, an immune dialogue emerges between immune and cancer cells orchestrated through a number of activated molecular pathways. Cytokines, encompassing migration inhibitory factor, transforming growth factor beta 1, tumor necrosisfactor-α, Interleukin(IL)-6, IL-10, IL-12, IL-17, IL-23 have been reported to be involved in human cancer development. Some cytokines, namely IL-5, IL-6, IL-10, IL-22 and growth factors promote tumor development and metastasis, and inhibit apoptosis via activation of signal transducer activator transcription-3 transcription factor. Colon cancer environment comprises mesenchymal, endothelial and immune cells. Assessment of the interaction between components in the tumor environment and malignant cells requires a reconsideration of a few topics elucidating the role of chronic inflammation in carcinogenesis, the function of the immune cells expressed by inflammatory cytokine production, the immunomodulation of cancer cells and the existence of a cross-talk between immune and malignant cells leading to a balance in cytokine production. It is conceivable that the prevalence of anti-inflammatory cytokine production by PBMC in the affected colonic mucosa will contribute to the delay, or even to halt down malignant expansion. Targeting the interplay between immune and cancer cells by mediators capable to alter cytokine secretion toward increased anti-inflammatory cytokine release by PBMC and tumor associated macrophages, may serve as an additional strategy for treatment of malignant diseases. This review will focus on the inflammatory events preceding tumorigenesis in general, and on a number of modulators capable to affect colon cancer cell-induced production of inflammatory cytokines by PBMC through alteration of the immune crosstalk between PBMC and cancer cells. The link between chronic inflammation and colorectal cancer has been well established. The events proceeding along tumorigenesis are complicated and involve cells activated at the cancer microenvironment, tumor infiltrating polymorphonuclears, immune cells including lymphocyte subtypes and peripheral blood mononuclear cells(PBMC), as well as tumor-associated macrophages. The immune cells generate inflammatory cytokines, several of them playing a crucial role in tumorigenesis. Additional factors, such as gene expression regulated by cytokines, assembling of tumor growth- and transforming factors, accelerated angiogenesis, delayed apoptosis, contribute all to initiation, development and migration of tumor cells. Oxygen radical species originating from the inflammatory area promote cell mutation and cancer proliferation. Tumor cells may over-express pro-inflammatory mediators that in turn activate immune cells for inflammatory cytokines production. Consequently, an immune dialogue emerges between immune and cancer cells orchestrated through a number of activated molecular pathways. Cytokines, encompassing migration inhibitory factor, transforming growth factor beta 1, tumor necrosisfactor-α, Interleukin(IL)-6, IL-10, IL-12, IL-17, IL-23 have been reported to be involved in human cancer development. Some cytokines, namely IL-5, IL-6, IL-10, IL-22 and growth factors promote tumor development and metastasis, and inhibit apoptosis via activation of signal transducer activator transcription-3 transcription factor. Colon cancer environment comprises mesenchymal, endothelial and immune cells. Assessment of the interaction between components in the tumor environment and malignant cells requires a reconsideration of a few topics elucidating the role of chronic inflammation in carcinogenesis, the function of the immune cells expressed by inflammatory cytokine production, the immunomodulation of cancer cells and the existence of a cross-talk between immune and malignant cells leading to a balance in cytokine production. It is conceivable that the prevalence of anti-inflammatory cytokine production by PBMC in the affected colonic mucosa will contribute to the delay, or even to halt down malignant expansion. Targeting the interplay between immune and cancer cells by mediators capable to alter cytokine secretion toward increased anti-inflammatory cytokine release by PBMC and tumor associated macrophages, may serve as an additional strategy for treatment of malignant diseases. This review will focus on the inflammatory events preceding tumorigenesis in general, and on a number of modulators capable to affect colon cancer cell-induced production of inflammatory cytokines by PBMC through alteration of the immune crosstalk between PBMC and cancer cells.
出处 《World Journal of Gastrointestinal Oncology》 SCIE CAS 2014年第5期129-138,共10页 世界胃肠肿瘤学杂志(英文版)(电子版)
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参考文献12

  • 1Wonmo Kang,Sujin Lee,Eunyi Jeon,Kook-Hyun Kim,Jun-Hyeog Jang.Emerging role of vitamin D in colorectal cancer[J].World Journal of Gastrointestinal Oncology,2011,3(8):123-127. 被引量:1
  • 2Ming-Yu Lai Jie-An Huang Zhi-Hai Liang Hai-Xing Jiang Guo-Du Tang.Mechanisms underlying aspirin-mediated growth inhibition and apoptosis induction of cyclooxygenase-2 negative colon cancer cell line SW480[J].World Journal of Gastroenterology,2008,14(26):4227-4233. 被引量:12
  • 3Sarah Shigdar,Yong Li,Santanu Bhattacharya,Michael O’Connor,Chunwen Pu,Jia Lin,Tao Wang,Dongxi Xiang,Lingxue Kong,Ming Q. Wei,Yimin Zhu,Shufeng Zhou,Wei Duan.Inflammation and cancer stem cells[J].Cancer Letters.2014(2)
  • 4Gerhard Rogler.Chronic ulcerative colitis and colorectal cancer[J].Cancer Letters.2014(2)
  • 5Laure Belmont,Nathalie Rabbe,Martine Antoine,Dominique Cathelin,Christophe Guignabert,Jonathan Kurie,Jacques Cadranel,Marie Wislez.Expression of TLR9 in tumor‐infiltrating mononuclear cells enhances angiogenesis and is associated with a worse survival in lung cancer[J].Int J Cancer.2014(4)
  • 6Eun‐Seok Park,Jae‐Myung Yoo,Hwan‐Soo Yoo,Do‐Young Yoon,Yeo‐Pyo Yun,JinTae Hong.IL‐32γ enhances TNF‐α‐induced cell death in colon cancer[J].Mol Carcinog.2014(S1)
  • 7Ryan Kolb,Guang-Hui Liu,Ann M. Janowski,Fayyaz S. Sutterwala,Weizhou Zhang.nflammasomes in cancer: a double-edgecl sword[J].Protein & Cell,2014,5(1):12-20. 被引量:39
  • 8Hertzel Salman,Michael Bergman,Naava Blumberger,Meir Djaldetti,Hanna Bessler.Do androgen deprivation drugs affect the immune cross-talk between mononuclear and prostate cancer cells?[J].Biomedicine & Pharmacotherapy.2013
  • 9O. Rodríguez‐Fandi?o,J. Hernández‐Ruíz,Y. López‐Vidal,L. Charúa,H. Bandeh‐Moghaddam,A. Minzoni,C. Guzmán,M. Schmulson.Intestinal recruiting and activation profiles in peripheral blood mononuclear cells in response to pathogen‐associated molecular patterns stimulation in patients with IBS[J].Neurogastroenterol Motil.2013(11)
  • 10Barry J. Laird,Stein Kaasa,Donald C. McMillan,Marie T. Fallon,Marianne J. Hjermstad,Peter Fayers,Pal Klepstad.Prognostic Factors in Patients with Advanced Cancer: A Comparison of Clinicopathological Factors and the Development of an Inflammation-Based Prognostic System[J].Clinical Cancer Research.2013(19)

二级参考文献63

  • 1[1]Reddy BS,Rao CV,Rivenson A,Kelloff G.Inhibitory effect of aspirin on azoxymethane-induced colon carcinogenesis in F344 rats.Carcinogenesis 1993; 14:1493-1497
  • 2[2]Garcia Rodriguez LA,Huerta-Alvarez C.Huerta-Alvarez C.Reduced incidence of colorectal adenoma among long-term users of nonsteroidal antiinflammatory drugs:a pooled analysis of published studies and a new population-based study.Epidemiology 2000; 11:376-381
  • 3[3]Garcia Rodriguez LA,Huerta-Alvarez C.Reduced risk of colorectal cancer among long-term users of aspirin and nonaspirin nonsteroidal antiinflammatory drugs.Epidemiology 2001; 12:88-93
  • 4[4]Barnes CJ,Lee M.Chemoprevention of spontaneous intestinal adenomas in the adenomatous polyposis coli Min mouse model with aspirin.Gastroenterology 1998; 114:873-877
  • 5[5]Plummer SM,Holloway KA,Manson MM,Munks RJ,Kaptein A,Farrow S,Howells L.Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NFkappaB activation via the NIK/IKK signalling complex.Oncogene 1999; 18:6013--6020
  • 6[6]Marrogi AJ,Travis WD,Welsh JA,Khan MA,Rahim H,Tazelaar H,Pairolero P,Trastek V,Jett J,Caporaso NE,Liotta LA,Harris CC.Nitric oxide synthase,cyclooxygenase 2,and vascular endothelial growth factor in the angiogenesis of non-small cell lung carcinoma.Clin Cancer Res 2000; 6:4739-4744
  • 7[7]Janne PA,Mayer RJ.Chemoprevention of colorectal cancer.N Engl J Med 2000; 342:1960-1968
  • 8[8]Richter M,Weiss M,Weinberger I,Furstenberger G,Marian B.Growth inhibition and induction of apoptosis in colorectal tumor cells by cyclooxygenase inhibitors.Carcinogenesis 2001; 22:17-25
  • 9[9]Thompson WJ,Piazza GA,Li H,Liu L,Fetter J,Zhu B,Sperl G,Ahnen D,Pamukcu R.Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition,protein kinase G activation,and attenuated beta-catenin.Cancer Res 2000; 60:3338-3342
  • 10[10]Hanif R,Pittas A,Feng Y,Koutsos MI,Qiao L,Staiano Coico L,Shift SI,Rigas B.Effects of nonsteroidal antiinflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin independent pathway.Biochem Pharmaco11996; 52:237-245

共引文献49

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  • 1Tao Li,Mei Ha Leong,Bruce Harms,Gregory Kennedy,Lin Chen.MicroRNA-21 as a potential colon and rectal cancer biomarker[J].World Journal of Gastroenterology,2013,19(34):5615-5621. 被引量:16
  • 2丁连安,黎介寿,李幼生,朱念庭,刘放南,谭力.创伤及内毒素对大鼠肠屏障功能的损害[J].中华实验外科杂志,2004,21(6):697-699. 被引量:19
  • 3Benjamin P. Lewis,Christopher B. Burge,David P. Bartel.Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets[J]. Cell . 2005 (1)
  • 4Jun Lu,Gad Getz,Eric A. Miska,Ezequiel Alvarez-Saavedra,Justin Lamb,David Peck,Alejandro Sweet-Cordero,Benjamin L. Ebert,Raymond H. Mak,Adolfo A. Ferrando,James R. Downing,Tyler Jacks,H. Robert Horvitz,Todd R. Golub.MicroRNA expression profiles classify human cancers. Nature . 2005
  • 5Ichimi Takahiro,Enokida Hideki,Okuno Yasushi,Kunimoto Ryo,Chiyomaru Takeshi,Kawamoto Ken,Kawahara Kazuya,Toki Kazuki,Kawakami Kazumori,Nishiyama Kenryu,Tsujimoto Gozoh,Nakagawa Masayuki,Seki Naohiko.Identification of novel microRNA targets based on microRNA signatures in bladder cancer. International journal of cancer. Journal international du cancer . 2009
  • 6Swiderska M,Choromańska B,Dbrowska E,Konarzewska-Duchnowska E,Choromańska K,Szczurko G,Myliwiec P,Dadan J,Ladny JR,Zwi-erz K.The diagnostics of colorectal cancer. Contemporary Oncology . 2014
  • 7Mahon SM.Microsatellite testing in colon cancer. Oncology Nursing Forum . 2014
  • 8Duan X,Hu J,Wang Y,Gao J,Peng D,Xia L.Micro RNA-145:a promising biomarker for hepatocellular carcinoma (HCC). Gene . 2014
  • 9Raghu R. Chivukula,Guanglu Shi,Asha Acharya,Eric W. Mills,Lauren R. Zeitels,Joselin L. Anandam,Abier A. Abdelnaby,Glen C. Balch,John C. Mansour,Adam C. Yopp,Anirban Maitra,Joshua T. Mendell.??An Essential Mesenchymal Function for miR-143/145 in Intestinal Epithelial Regeneration(J)Cell . 2014 (5)
  • 10Jufeng Zhang,Xia Luo,Huiming Li,Xupeng Yue,Lin Deng,Yuanyuan Cui,Yanxin Lu.??MicroRNA-223 functions as an oncogene in human colorectal cancer cells(J)Oncology Reports . 2014 (1)

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