期刊文献+

On biomarkers and pathways in rectal cancer: What's the target? 被引量:1

On biomarkers and pathways in rectal cancer: What’s the target?
下载PDF
导出
摘要 In spite of tremendous progresses in surgical and chemo-radiotherapeutic regimens, rectal cancer still suffers from high relapse and mortality rates, and metastatic disease is incurable. Here we assess some of the most recent and validated biomarkers and potential targets studied in rectal cancer, and provide comments to a recent monographic topic covering several aspects of colorectal cancer, published in Current Cancer Drug Targets . In spite of tremendous progresses in surgical and chemo-radiotherapeutic regimens, rectal cancer still suffers from high relapse and mortality rates, and metastatic disease is incurable. Here we assess some of the most recent and validated biomarkers and potential targets studied in rectal cancer, and provide comments to a recent monographic topic covering several aspects of colorectal cancer, published in Current Cancer Drug Targets .
出处 《World Journal of Gastrointestinal Surgery》 SCIE CAS 2012年第12期275-277,共3页 世界胃肠外科杂志(英文版)(电子版)
关键词 RECTAL cancer COLORECTAL surgery Chemo- THERAPY TARGETED molecular THERAPY Biological MARKERS Rectal cancer Colorectal surgery Chemo- therapy Targeted molecular therapy Biological markers
  • 相关文献

参考文献26

  • 1Bengala C,Bettelli S,Bertolini F,et al.Epidermal growth factor ??receptor gene copy number,K-ras mutation and pathological response topreoperative cetuximab,5-FU and radiationtherapy in locally advanced rectal cancer. Annals of Oncology . 2009
  • 2Lopez-CrapezE,Bibeau F,Thezenas S,Ychou M,Simony- Lafontaine J,Thirion A,Azria D,Grenier J,Senesse P.p53 status and response to radiotherapy in rectal cancer: a prospective multilevel analysis. British Journal of Cancer . 2005
  • 3I. Zlobec,R. Steele,C.C. Compton.VEGF as a predictive marker of rectal tumor response to preoperative radiotherapy. Cancer . 2005
  • 4Iglehart JD,Silver DP.Synthetic lethality-a new direction in cancer-drug development. The New England Journal of Medicine . 2009
  • 5Kholodenko B,Yaffe MB,Kolch W.Computational ap- proaches for analyzing information flow in biological net- works. Sci Signal . 2012
  • 6Hoos A,Nissan A,Stojadinovic A,et al.Tissue microarray molecular profiling of early, node-negative adenocarcinoma of the rectum: a comprehensive analysis. Clinical Cancer Research . 2002
  • 7Rau B,Sturm I,Lage H,et al.Dynamic expression profile of p21WAF1/CIP1 and Ki-67 predicts survival in rectal carcinoma treated with preoperative radiochemotherapy. Journal of Clinical Oncology . 2003
  • 8Ghadimi BM,Grade M,Difilippantonio MJ, et al.Effectiveness of gene expression profiling for response prediction of rectal adenocarcinomas to preoperative chemoradiotherapy. Journal of Clinical Oncology . 2005
  • 9S Huerta,J Hrom,X Gao.Tissue microarray constructs to predict a response to chemoradiation in rectal cancer. Digestive and Liver Disease . 2010
  • 10Ballestrero A,Garuti A,Cirmena G, et al.Patient-Tailored Treatments with Anti-EGFR Monoclonal Antibodies in Advanced Colorectal Cancer:KRAS and Beyond. Current Cancer Drug Targets . 2012

同被引文献3

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部