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Targeting leukemia stem cells:The new goal of therapy in adult acute myeloid leukemia

Targeting leukemia stem cells:The new goal of therapy in adult acute myeloid leukemia
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摘要 The most popular view of hematopoietic cell lineage organization is that of complex reactive or adaptative systems.Leukemia contains a subpopulation of cells that display characteristics of stem cells.These cells maintain tumor growth.The properties of leukemia stem cells indicate that current conventional chemotherapy, directed against the bulk of the tumor,will not be effective.Leukemia stem cells are quiescent and do not respond to cell cycle-specific cytotoxic agents used to treat leukemia and thus contribute to treatment failure. New strategies are required that specifically target this malignant stem cell population. The most popular view of hematopoietic cell lineage organization is that of complex reactive or adaptative systems. Leukemia contains a subpopulation of cells that display characteristics of stem cells. These cells maintain tumor growth. The properties of leukemia stem cells indicate that current conventional chemotherapy, directed against the bulk of the tumor, will not be effective. Leukemia stem cells are quiescent and do not respond to cell cycle-specific cytotoxic agents used to treat leukemia and thus contribute to treatment failure. New strategies are required that specifically target this malignant stem cell population.
作者 Xavier Thomas
机构地区 Department of Hematology
出处 《World Journal of Stem Cells》 SCIE CAS 2009年第1期49-54,共6页 世界干细胞杂志（英文版）（电子版）
关键词 Acute MYELOID LEUKEMIA LEUKEMIA stem cells TARGETED THERAPY Prognosis Acute myeloid leukemia Leukemia stem cells Targeted therapy Prognosis
分类号 R733.7 [医药卫生—肿瘤]
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  • 1Thomas X,Raffoux E,Botton S,Pautas C,Arnaud P,de Revel T,Reman O,TerréC,Corront B,Gardin C,Le QH,Quesnel B,Cordonnier C,Bourhis JH,Elhamri M,Fenaux P,Preudhomme C,Michallet M,Castaigne S,Dombret H.Effect of priming with granulocyte-macrophage colony-stimulating factor in younger adults with newly diagnosed acute myeloid leukemia:a trial by the Acute Leukemia French Association (ALFA)Group. Leukemia . 2007
  • 2Andreeff M,Konoplev S,Wang RY,Zeng Z,McQueen T,Shi YX,Medeiros LJ,Estey E,McCarty JM,Elkins S,Champlin R,Calandra G,Bridger G,Konopleva M.Massive mobilization of AML cells into circulation by disruption of leukemia/stroma cell interactions using CXCR4 antagonist AMD3100:First evidence in patients and potential for abolishing bone marrow microenvironment-mediated resistance. Blood . 2006
  • 3Jin L,Lee EM,Ramshaw HS,Busfield SJ,Peoppl AG,Wilkinson L,Guthridge MA,Thomas D,Barry EF,Boyd A,Gearing DP,Vairo G,Lopez AF,Dick JE,Lock RB.Monoclonal antibody-mediated targeting of CD123,IL-3 receptor alpha chain,eliminates human acute myeloid leukemic stem cells. Cell Stem Cell . 2009
  • 4Suda T,Suda J,Ogawa M.Disparate differentiation in mouse hemopoietic colonies derived from paired progenitors. Proceedings of the National Academy of Sciences of the United States of America . 1984
  • 5Kirkland M,Borokov K.A phase space model of hemopoiesis [abstract]. Experimental Hematology . 2002
  • 6Roeder I,Loeffler M.Anovel dynamic model of hematopoietic stem cell organization based on the concept of within-tissue plasticity. Experimental Hematology . 2002
  • 7Gal H,Amariglio N,Trakhtenbrot L,Jacob-Hirsh J,Margalit O,Avigdor A,Nagler A,Tavor S,Ein-Dor L,Lapidot T,Domany E,Rechavi G,Givol D.Gene expression profiles of AML derived stem cells;similarity to hematopoietic stem cells. Leukemia . 2006
  • 8de Grouw EP,Raaijmakers MH,Boezeman JB,van der Reijden BA,van de Locht LT,de Witte TJ,Jansen JH,Raymakers RA.Preferential expression of a high number of ATP binding cassette transporters in both normal and leukemic CD34+CD38-cells. Leukemia . 2006
  • 9Lwenberg B,van Putten W,Theobald M,Gmür J,Verdonck L,Sonneveld P,Fey M,Schouten H,de Greef G,Ferrant A,Kovacsovics T,Gratwohl A,Daenen S,Huijgens P,Boogaerts M.Effect of priming with granulocyte colony- stimulating factor on the outcome of chemotherapy for acute myeloid leukemia. The New England Journal of Medicine . 2003
  • 10Bakker AB,van den Oudenrijn S,Bakker AQ,Feller N,van Meijer M,Bia JA,Jongeneelen MA,Visser TJ,Bijl N,Geuijen CA,Marissen WE,Radosevic K,Throsby M,Schuurhuis GJ,Ossenkoppele GJ,de Kruif J,Goudsmit J,Kruisbeek AM.C-type lectin-like molecule-1:a novel myeloid cell surface marker associated with acute myeloid leukemia. Cancer Research . 2004

共引文献15

World Journal of Stem Cells
2009年 第1期

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