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Effects of nanotopography on stem cell phenotypes 被引量：3

Effects of nanotopography on stem cell phenotypes
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摘要 Stem cells are unspecialized cells that can self renew indefinitely and differentiate into several somatic cells given the correct environmental cues.In the stem cell niche,stem cell-extracellular matrix(ECM)interactions are crucial for different cellular functions,such as adhesion,proliferation,and differentiation.Recently, in addition to chemical surface modifications,the importance of nanometric scale surface topography and roughness of biomaterials has increasingly becoming recognized as a crucial factor for cell survival and host tissue acceptance in synthetic ECMs.This review describes the influence of nanotopography on stem cell phenotypes. Stem cells are unspecialized cells that can self renew indefinitely and differentiate into several somatic cells given the correct environmental cues. In the stem cell niche, stem cell-extracellular matrix (ECM) interactions are crucial for different cellular functions, such as adhesion, proliferation, and differentiation. Recently, in addition to chemical surface modifications, the importance of nanometric scale surface topography and roughness of biomaterials has increasingly becoming recognized as a crucial factor for cell survival and host tissue acceptance in synthetic ECMs. This review describes the influence of nanotopography on stem cell phenotypes.
作者 Rajeswari Ravichandran Clarisse CH Ng Casey K Chan Michael Raghunath Seeram Ramakrishna
机构地区 Division of Bioengineering Department of Mechanical Engineering Nanoscience and Nanotechnology Initiative Department of Restorative Dentistry Department of Orthopaedic Surgery Department of Biochemistry
出处 《World Journal of Stem Cells》 SCIE CAS 2009年第1期55-66,共12页 世界干细胞杂志（英文版）（电子版）
基金 Supported by The National University of Singapore,Grant No.R-224-000-035-133 and NMRC/1151/2008,Singapore
关键词 Stem cells NANOFIBERS NANOTOPOGRAPHY BIOMATERIALS EXTRACELLULAR matrix Differentiation Stem cells Nanofibers Nanotopography Biomaterials Extracellular matrix Differentiation
分类号 Q813 [生物学—生物工程]
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参考文献118

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共引文献26

同被引文献65

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引证文献3

二级引证文献5

World Journal of Stem Cells
2009年 第1期

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