摘要
OBJECTIVE: To assess the influence of different drainage procedures on the levels of serum endoloxinand tumor necrosis factor (TNF) in patients with malignant obstructive jaundice (MOJ).METHODS: The levels of endotoxin and TNF in 46 patients with MOJ were measured before and aftercholangiojejunostomy (CJ) or external bile drainage (EBD).RESULTS: In the CJ group, the levels of postoperative serum endotoxin and TNF 10 days after operationwere significantly lower than those before operation (P【0.01). In the EBD group, no significant changeswere observed in endotoxin and TNF levels before and after operation (P】0.05). No significantdifferences were seen between the two groups before operation (P】0.05), but the levels of endotoxin andTNF in the CJ group were significantly lower than those in the EBD group after operation (P【0. 01).CONCLUSIONS: Cholangiojejunostomy other than external bile drainage can decrease the levels ofserum endotoxin and TNF effectively, although both of them are able to release jaundice.Cholangiojejunostomy should be performed as soon as possible for patients with unresectable malignanttumor.
