摘要
Objective: To investigate the relation of transfergrowth factor （TGF-β<sub>1</sub>） and β-glucuronidase （β-GCD） on the occurrence and progress of pancreaticcancer.Methods: The expression of TGF-β<sub>1</sub> and β-GCD in thepancreatic cancer tissue and normal pancreatic tissuewas determined synchronously using ABC method ofimmunohistochemistry.Results: The percentage of TGF-β<sub>1</sub> positive cells wassignificantly higher in pancreatic cancer tissue （43.8%±5.2%） than in adjacent pancreatic tissue （28.7%±3.6%, P【0.01）. The worse the cancer cells differen-tiated and lymph nodes metastasis, the more over-ex-pression of TGF-β<sub>1</sub>. The percentage of β-GCD positivecells was also significantly higher in the pancreaticcancer tissue （62.5%±4.1%） than in the adjacentpancreatic tissue （33.5%±2.8%, P【0.01）. The de-gree of over-expression of β-GCD was related to thedegree of cancer cells differentiation, but not to thelymph nodes metastasis. The expression of TGF-β<sub>1</sub>was significantly correlated with the expression of β-GCD in pancreatic cancer tissue.Conclusions: The genesis of pancreatic cancer resultsfrom multi-factor, multi-step and multi-gene varia-tion. The synchronous detection of TGF-β<sub>1</sub> and β-GCD helps to determine the malignant degree oftumors and the prognosis of patients with such disease.
