摘要
Objectives: To prevent and early diagnose hepatitis B virus reinfection and recurrent hepatitis B following liver transplantation, and to discuss the further treat- ment of recurrent hepatitis B. Methods: Liver transplantation recipients received lamivudine for prophylaxis of HBV reinfection. Viro- logical and biochemical data, serum HBV-DNA, and immunohistological staining for HBsAg and HBcAg in liver biopsy specimens were tested in due time. Results: Five patients with hepatitis B virus reinfection and two patients with hepatitis B recurrence were ob- served after liver transplantation. One patient with re- current hepatitis B developed chronic severe hepatitis B despite treatment. One patient improved after a se- ries of treatment. Conclusions: Hepatitis B virus reinfection or recurrent hepatitis B following liver transplantation occurs most- ly 6-12 months after operation. The diagnosis of hepa- titis B recurrence should be taken into account when liver biochemical data becomes poor during this pe- riod. The treatment for recurrent hepatitis B after liv- er transplantation includes increased dosage of lamivu- dine, application of famciclovir, and other liver pro- tection measures.
Objectives: To prevent and early diagnose hepatitis B virus reinfection and recurrent hepatitis B following liver transplantation, and to discuss the further treat- ment of recurrent hepatitis B. Methods: Liver transplantation recipients received lamivudine for prophylaxis of HBV reinfection. Viro- logical and biochemical data, serum HBV-DNA, and immunohistological staining for HBsAg and HBcAg in liver biopsy specimens were tested in due time. Results: Five patients with hepatitis B virus reinfection and two patients with hepatitis B recurrence were ob- served after liver transplantation. One patient with re- current hepatitis B developed chronic severe hepatitis B despite treatment. One patient improved after a se- ries of treatment. Conclusions: Hepatitis B virus reinfection or recurrent hepatitis B following liver transplantation occurs most- ly 6-12 months after operation. The diagnosis of hepa- titis B recurrence should be taken into account when liver biochemical data becomes poor during this pe- riod. The treatment for recurrent hepatitis B after liv- er transplantation includes increased dosage of lamivu- dine, application of famciclovir, and other liver pro- tection measures.
