川芎和香附超临界CO2提取物及其制剂的体外经皮透过性

In vitro transdermal permeation behaviors of Supercritical CO2 Extracted Essential Oil from Ligusticum chuanxiong Hort. and and Cyperus rotundus L. and oil containing hydrogel patch

目的考察川芎和香附超临界 CO2提取物及其水凝胶贴剂的体外经皮透过性。方法实验采用 Franz 扩散装置,分别以藁本内酯和α-香附酮为川芎和香附提取物的指标成分,考察提取物及其水凝胶贴剂经离体大鼠皮肤的透过性。结果川芎和香附超临界 CO2 提取物中的多种成分均具有经皮透过性,提取物的比例不同对指标成分的经皮透过性无明显影响。结论经皮给药可望作为川芎和香附超临界 CO2提取物的一种新的给药途径。

Object To investigate the in vitro transdermal permeation behavior of supercritical CO2 extracted essential oils from Ligusticum chuanxiong Hort. and Cyperus rotundus L. and the hydrogel patch containing the extracted oil. Methods Franz diffusion devices were used for in vitro transdermal permeation test with full rat skin as the model membrane. Ligustilide and α-cyperone were used as the index ingredients to evaluate the transdermal permeation of the extracts and the patch formulation. Results The results showed that most of the ingredients in the extracts can permeate across the rat skin in vitro, and ratio of two extracts in the mixture did not affect the transdermal permeability of the two index ingredients obviously. Conclusion The present results showed great potential of percutanous administration of the supercritical CO2 extracted essential oil from Ligusticum chuanxiong Hort. and Cyperus rotundus L..