摘要
目的对五味消毒饮分散片的处方进行优化,并考察其制备工艺,以提高有效成分溶出度,使传统中药得到更有效的应用。方法以崩解时限及溶出百分率为指标,采用正交设计筛选最佳处方和工艺。结果优选出最佳处方:微晶纤维素(MCC)为填充剂,交联羧甲基纤维素纳(CCMC-Na)和交联聚乙烯吡咯烷酮(PVPP)为崩解剂,质量分数为95%的乙醇为黏合剂,湿法制粒制备分散片。结论所制备的分散片处方合理,崩解快,溶出迅速而完全。
Objective To investigate the optimum formulation and preparation process of Wuweixiaoduyin dispersible tablets.Methods The formula of Wuweixiaoduyin dispersible tablets were optimized in terms of disintegration time and dissolution percent by orthogonal design test.Results The tablets were prepared by moist granulation method with alcohol(95%) as moistening agent, microcrystalling cellulose(MCC) as diluents, and the polyvinylpolyrrolidone(PVPP) and sodium croscarboxymethylcellulose(CCMC-Na) as disintegrant.Conclusion The formula of the dispersible tablets is reasonable, with faster disintegration and more complete dissolution.
出处
《中国药剂学杂志（网络版）》
2008年第3期109-115,共7页
Chinese Journal of Pharmaceutics：Online Edition
关键词
药剂学
分散片
正交设计
五味消毒饮
制备
pharmaceutics
dispersible tablets
orthogonal design
Wuweixiaoduyin
preparation
