长效微球注射剂及其在糖尿病治疗领域中的应用

The Progress of protein/peptide microspheres for diabetes mellitus

随着新型释药系统的研究和发展,长效微球注射剂已引起广泛关注。DNA重组人胰岛素等用于治疗糖尿病的生物技术药物经长效微球注射剂给药后可以减少糖尿病人所需的多次注射,使药物治疗更易接受。作者综述了近年来长效微球注射剂的研究进展,提示此种新型释药系统在治疗糖尿病的药物中,将成为一个很有希望的给药途径。

In recent years,biodegradable microspheres have been widely used for long-term controlled delivery of various peptides and proteins in order to improve the efficacy of drugs and eliminate the need for frequent administration.In this paper,the progress of protein/peptide microspheres for diabetes mellitus are reviewed.