对土坝茛草的化学成分研究

Studies of the Chemical Constituents of Salvia Plebeian R Br.

目的:对土坝莨草(Salvia plebeian R Br.)全草70%(v/v)乙醇提取物的化学成分进行研究。方法:利用反复硅胶柱色谱、制备薄层、SENFadex LH-20、开放ODS柱色谱等方法进行分离纯化;根据理化性质及波谱分析对分离得到的化合物进行结构研究。结果:分离得到11个化合物,分别鉴定为咖啡酸甲酯(caffeic acid methyl ester,1),东莨菪素(scopoletin,2),carnosol(3),rosmadial(4),熊果酸(ursolic acid,5),柳穿鱼素(pectolinarigenin,6),表迷迭香酚(epirosmanol,7),高车前素(hispidulin,8),高车前苷(homoplantaginin,9),泽兰黄酮(nepetin,10),-谷甾醇(-sitosterol,11)。结论:化合物1、2为首次从该属植物中分离得到,化合物3～7为首次从该植物中分离得到。

Objective To study the chemical constituents of Salvia plebeian R Br.Methods Compounds were isolated and purified repeatedly by silica gel column,preparative TLC,SENFadex LH-20 gel column and ODS column chromatography,and their chemical structures were elucidated by their physi-cochemical properties and spectral analysis.Results Eleven compounds were obtained and identified as caffeic acid methyl ester(1),scopoletin(2),carnosol(3),rosmadial(4),ursolic acid(5), pectolinarigenin(6),epirosmanol(7),hispidulin(8),homoplantaginin(9),nepetin(10),-sitosterol (11).Conclusion Compounds 1 and 2 are odtained from the Salvia genus for the first time,Compounds 3～7 are reported from this plant for the first time.